HIPK4AR (à confirmer)medRxivNew gene
HIPK4 is a novel gene associated with teratozoospermia
Consortium international — medRxiv preprint
Relevance score
7/10
Disease / domain
Male infertility — teratozoospermia
Week
22 April 2026
Variant / mechanism
HIPK4 (rare variants — candidate new gene)
Functional validation (spermatogenesis, spermatozoon morphology)
Summary
Proposal of HIPK4 as a new teratozoospermia gene, based on the identification of rare variants in patients with spermatozoon morphological abnormalities, complemented by functional analysis of HIPK4's role in spermatogenesis.
Synthesis written by Geno'X. For the full original abstract, please refer to the source publication.
Analysis
To be added to teratozoospermia panels. Relevant functional validation but limited cohort size — to watch for consolidated publication.
Why this score?
new gene +3; functional analysis +2; limited cohort +0; preprint −1; panel impact +1; infertility-specific +2
Keywords
HIPK4teratozoospermiamale infertility