ACT-ON: Assisted cascade testing via outreach and navigation - Real-world experience with clinician-initiated, third-party-facilitated family cascade testing

BRCA1, BRCA2 (family cascade)

Assisted cascade testing program (ACT-ON): proactive outreach to relatives of BRCA1/2 probands, facilitation by third parties (patient navigators); assessment of testing rate and number of carriers identified in real-world experience

Evaluation of the ACT-ON assisted cascade testing program in gynecologic oncology. The program deploys patient navigators to proactively contact first-degree relatives of probands with pathogenic BRCA1/2 variants. The real-world experience demonstrates a significant increase in testing rates among eligible relatives compared to traditional proband-family communication, with reduced delays between proband identification and relative testing.

Synthesis written by Geno'X. For the full original abstract, please refer to the source publication.

Cascade testing remains underused in France and Europe: only a minority of eligible relatives get tested after proband identification. The proactive ACT-ON model, with a third-party facilitator, is potentially applicable to the French context (via oncogeneticists and multidisciplinary teams). To be placed on the MDT agenda.

proactive real-world cascade testing +2; impact on number of identified carriers +2; potentially exportable model +2; Gynecol Oncol +1