ATM
HGNC ↗2 article(s) in the watch · Cancer genetics
ATM encodes a kinase central to the DNA double-strand break response. Monoallelic variants confer a moderate cancer risk; biallelic variants cause ataxia-telangiectasia.
Curated publications
Reclassification of ATM Missense Variants of Uncertain Significance by Integrating Results from Systematic Functional Assays into an ACMG Points-Based Framework
Hereditary predisposition to breast and pancreatic cancer (moderate penetrance)
Report of Multilocus Inherited Neoplasia Alleles Syndrome in a Chilean Oncology Institute: New Combinations and Genetic Landscape.
Multilocus inherited neoplasia alleles syndrome
Frequently asked questions
How is a ATM-related condition inherited?+
Dominant (moderate risk); recessive for ataxia-telangiectasia
What is the clinical spectrum associated with ATM?+
Breast, pancreas (heterozygous carriers)
What is the management associated with ATM?+
Tailored breast surveillance; caution with radiation in biallelic individuals.
How many Geno'X publications cover the ATM gene?+
2 publication(s) on ATM have been selected, summarised and scored by Geno'X on a public grading grid (domains: Cancer genetics).
