Pharmacogenomics

The main pharmacogenes, the drugs involved, their recommendation level (CPIC, RNPGx) and evidence level (PharmGKB/ClinPGx). Each gene links to its page and the related Geno'X bibliographic watch.

CYP2C19

Level APharmGKB 1A28 art.

clopidogrel, voriconazole, antidepressants (citalopram, escitalopram, sertraline, amitriptyline), proton-pump inhibitors

CPIC level A · RNPGx advised (antidepressants)

CYP2D6

Level APharmGKB 1A17 art.

codeine and tramadol (opioids), tamoxifen, tricyclic antidepressants, SSRIs (paroxetine, fluvoxamine), atomoxetine, ondansetron

CPIC level A · RNPGx advised (antidepressants)

DPYD

Level APharmGKB 1A11 art.

fluoropyrimidines: 5-fluorouracil, capecitabine, tegafur

CPIC level A · RNPGx "essential" (DPD deficiency screening)

CYP3A5

Level APharmGKB 1A7 art.

tacrolimus

CPIC level A

HLA-B

Level APharmGKB 1A6 art.

abacavir (*57:01), carbamazepine / oxcarbazepine / phenytoin (*15:02), allopurinol (*58:01)

CPIC level A · RNPGx essential (abacavir)

UGT1A1

Level APharmGKB 1A6 art.

irinotecan; atazanavir

Irinotecan: RNPGx "essential", FDA/DPWG (no dedicated CPIC guideline). Atazanavir: CPIC level A.

NUDT15

Level APharmGKB 1A3 art.

thiopurines: azathioprine, 6-mercaptopurine, 6-thioguanine

CPIC level A

TPMT

Level APharmGKB 1A3 art.

thiopurines: azathioprine, 6-mercaptopurine, 6-thioguanine

CPIC level A · RNPGx "essential"

CYP2C9

Level APharmGKB 1A2 art.

warfarin, NSAIDs, phenytoin, fluvastatin

CPIC level A

SLCO1B1

Level APharmGKB 1A1 art.

statins (notably simvastatin) — myopathy risk

CPIC level A

VKORC1

Level APharmGKB 1A1 art.

warfarin and vitamin-K antagonists

CPIC level A (with CYP2C9)

NAT2

Emerging4 art.

isoniazid, hydralazine, sulfonamides

Emerging evidence

CYP1A2

Emerging1 art.

clozapine, caffeine

Limited / emerging evidence

CYP3A4

—5 art.

many substrates (immunosuppressants, statins, calcium-channel blockers)

No dedicated CPIC guideline

Level A = supported prescribing recommendation (source shown per row). PharmGKB 1A = pair backed by a CPIC or medical-society guideline. Indicative, non-exhaustive list — refer to current guidelines.

Reference resources

ClinPGx ↗

PharmGKB + CPIC unified (evidence levels & guidelines)

RNPGx ↗

French national pharmacogenetics network

FDA PGx ↗

Table of pharmacogenetic associations

Frequently asked questions

What is pharmacogenomics?+

Pharmacogenomics studies how a patient's genetic variants influence their response to drugs (efficacy, risk of adverse reactions). It allows prescribing to be adapted — dose, drug choice or monitoring — according to the genetic profile.

What do CPIC levels A and B mean?+

CPIC (Clinical Pharmacogenetics Implementation Consortium) grades gene-drug pairs by how actionable they are. Level A: a prescribing change is recommended. Level B: a change may be considered. These levels guide the clinical use of genetic information.

What does this table contain?+

The main pharmacogenes, the drugs involved, the recommendation level (CPIC, RNPGx) and the evidence level (PharmGKB/ClinPGx). Each gene links to its dedicated page and the related Geno'X bibliographic watch.

Is this medical advice?+

No. This list is indicative and non-exhaustive, for orientation only. Always refer to the current official guidelines; it does not constitute medical advice.