CDH1
HGNC ↗3 article(s) in the watch · Cancer genetics
CDH1 encodes E-cadherin, a cell-adhesion protein. Germline loss of function causes hereditary diffuse gastric cancer and a risk of lobular breast cancer.
Curated publications
Predictors of early cancer burden in CDH1 pathogenic variant carriers: a UK single-centre cohort study.
Hereditary diffuse gastric cancer (HDGC)
Molecular characteristics and clinical outcomes of patients with gastroesophageal cancer diagnosed at ages younger than 50 years.
Early-onset gastroesophageal cancer (<50 years) — enrichment in germline CDH1 and TP53 variants
Endoscopic detection of signet ring cell carcinoma in CDH1 carriers: a 15-year single-centre experience.
Hereditary diffuse gastric cancer (CDH1 carriers)
Frequently asked questions
How is a CDH1-related condition inherited?+
Autosomal dominant
What is the clinical spectrum associated with CDH1?+
Diffuse gastric cancer, lobular breast cancer
What is the management associated with CDH1?+
Prophylactic total gastrectomy or expert endoscopic surveillance; breast surveillance.
How many Geno'X publications cover the CDH1 gene?+
3 publication(s) on CDH1 have been selected, summarised and scored by Geno'X on a public grading grid (domains: Cancer genetics).
