CDH1

1 article(s) in the watch · Cancer genetics

CDH1 encodes E-cadherin, a cell-adhesion protein. Germline loss of function causes hereditary diffuse gastric cancer and a risk of lobular breast cancer.

InheritanceAutosomal dominant

Clinical spectrumDiffuse gastric cancer, lobular breast cancer

ManagementProphylactic total gastrectomy or expert endoscopic surveillance; breast surveillance.

Curated publications

8/10

Molecular characteristics and clinical outcomes of patients with gastroesophageal cancer diagnosed at ages younger than 50 years.

Early-onset gastroesophageal cancer (<50 years) — enrichment in germline CDH1 and TP53 variants

Onco13 May 2026

External references

OMIM ↗GeneReviews ↗ClinVar ↗NCBI Gene ↗