CHEK2
HGNC ↗4 article(s) in the watch · Cancer genetics
CHEK2 encodes a cell-cycle checkpoint kinase. Pathogenic variants (including c.1100delC) confer a moderate cancer risk.
Curated publications
The pleiotropic landscape of rare variant associations with multiple cancers in large biobanks.
Inherited predisposition to multiple cancers
Incidence of Germline Genetic Variants in Patients with a Urinary Tract Cancer and Association with Outcomes.
Urinary tract cancer
Impact of updated NCCN guidelines on clinical management and risk communication for CHEK2 p.I157T carriers in breast cancer.
Breast cancer — CHEK2 p.I157T carriers
Recent advances in genetic predisposition to primary testicular tumors.
Genetic predisposition to primary testicular tumors (germ cell and stromal)
Frequently asked questions
How is a CHEK2-related condition inherited?+
Autosomal dominant
What is the clinical spectrum associated with CHEK2?+
Breast, colorectal (moderate risk)
What is the management associated with CHEK2?+
Enhanced breast surveillance according to family history.
How many Geno'X publications cover the CHEK2 gene?+
4 publication(s) on CHEK2 have been selected, summarised and scored by Geno'X on a public grading grid (domains: Cancer genetics).