← Gene index
CHEK2
HGNC ↗2 article(s) in the watch · Cancer genetics
CHEK2 encodes a cell-cycle checkpoint kinase. Pathogenic variants (including c.1100delC) confer a moderate cancer risk.
InheritanceAutosomal dominant
Clinical spectrumBreast, colorectal (moderate risk)
ManagementEnhanced breast surveillance according to family history.
Curated publications
6/10
Impact of updated NCCN guidelines on clinical management and risk communication for CHEK2 p.I157T carriers in breast cancer.
Breast cancer — CHEK2 p.I157T carriers
Onco28 July 2026
5/10Recent advances in genetic predisposition to primary testicular tumors.
Genetic predisposition to primary testicular tumors (germ cell and stromal)
Onco27 May 2026
Frequently asked questions
How is a CHEK2-related condition inherited?+
Autosomal dominant
What is the clinical spectrum associated with CHEK2?+
Breast, colorectal (moderate risk)
What is the management associated with CHEK2?+
Enhanced breast surveillance according to family history.
How many Geno'X publications cover the CHEK2 gene?+
2 publication(s) on CHEK2 have been selected, summarised and scored by Geno'X on a public grading grid (domains: Cancer genetics).
