CTNNA1

1 article(s) in the watch · Cancer genetics

CTNNA1 encodes alpha-E-catenin, a partner of E-cadherin. Pathogenic variants predispose to hereditary diffuse gastric cancer in CDH1-negative families.

InheritanceAutosomal dominant

Clinical spectrumDiffuse gastric cancer

ManagementEndoscopic surveillance; management in an oncogenetics setting.

Curated publications

8/10

Hereditary diffuse gastric cancer spectrum associated with germline CTNNA1 loss of function revealed by clinical and molecular comprehensive analysis

Hereditary diffuse gastric cancer (HDGC) spectrum — CTNNA1-related

Onco6 May 2026

External references

OMIM ↗GeneReviews ↗ClinVar ↗NCBI Gene ↗