CYP1A2

1 article(s) in the watch · Pharmacogenomics

CYP1A2 metabolises several drugs (caffeine, clozapine, theophylline) and is strongly inducible (smoking). Its activity, modulated by variants and environment, influences exposure to these substrates.

PharmacogenomicsEmerging

Drugs involved: clozapine, caffeine

Recommendation: Limited / emerging evidence

Pharmacogenomics guide ClinPGx (PharmGKB + CPIC) ↗

Curated publications

4/10

Effects of Repeated Smoking and Quitting Cigarettes on Plasma Concentrations of Clozapine and Its N-Desmethyl and N-Oxide Metabolites in a Japanese Patient With Schizophrenia.

Clozapine — CYP1A2 phenoconversion by smoking and smoking cessation

PGx3 June 2026

External references

OMIM ↗GeneReviews ↗ClinVar ↗NCBI Gene ↗