CYP1A2

1 article(s) in the watch · Pharmacogenomics

CYP1A2 metabolises several drugs (caffeine, clozapine, theophylline) and is strongly inducible (smoking). Its activity, modulated by variants and environment, influences exposure to these substrates.

PharmacogenomicsEmerging

Drugs involved: clozapine, caffeine

Recommendation: Limited / emerging evidence

Pharmacogenomics guide ClinPGx (PharmGKB + CPIC) ↗

Curated publications

4/10

Effects of Repeated Smoking and Quitting Cigarettes on Plasma Concentrations of Clozapine and Its N-Desmethyl and N-Oxide Metabolites in a Japanese Patient With Schizophrenia.

Clozapine — CYP1A2 phenoconversion by smoking and smoking cessation

PGx3 June 2026

Frequently asked questions

Which drugs are affected by CYP1A2 in pharmacogenomics?+

clozapine, caffeine — Limited / emerging evidence

How many Geno'X publications cover the CYP1A2 gene?+

1 publication(s) on CYP1A2 have been selected, summarised and scored by Geno'X on a public grading grid (domains: Pharmacogenomics).

External references

OMIM ↗GeneReviews ↗ClinVar ↗NCBI Gene ↗