Gene index

CYP3A5

HGNC ↗

7 article(s) in the watch · Pharmacogenomics

CYP3A5 influences the metabolism of tacrolimus, a narrow-therapeutic-index immunosuppressant. Expresser/non-expresser status (the *3 allele) determines the starting dose required to reach target concentrations (CPIC guidelines).

PharmacogenomicsLevel APharmGKB 1A

Drugs involved: tacrolimus

Recommendation: CPIC level A

Curated publications

7/10

Preemptive Pharmacogenetics in Renal Transplantation: A Real-World Assessment of Pharmacogenetic Actionability

Renal transplantation — preemptive pharmacogenetics

PGx23 June 2026
7/10

Integrating pharmacogenetic and clinical factors to predict the C0/D/W-based tacrolimus phenotype in kidney transplantation

Tacrolimus — pharmacogenetic prediction of pharmacokinetic phenotype (C0/D/W) in kidney transplantation by integrating CYP3A4/CYP3A5 variants and clinical factors

PGx10 June 2026
6/10

Effects of CYP3A4, CYP3A5, and ABCB1 genetic variants on tacrolimus metabolism during the early period after kidney transplantation

Kidney transplantation and tacrolimus exposure

PGx4 August 2026
6/10

A Review of Population Pharmacokinetic Models and Dosing Algorithms Assessing the Influence of CYP3A5 Genotype and Other Clinical Covariates on Tacrolimus Pharmacokinetics.

Organ transplantation — tacrolimus dosing

PGx21 July 2026
6/10

Population pharmacokinetics of tacrolimus and CYP3A5-driven variability: implications for model-informed dose individualization in pediatric renal transplant recipients.

Tacrolimus PK variability in pediatric renal transplantation

PGx16 June 2026
5/10

Toward individualized precision dosing of perampanel: Integrating therapeutic drug monitoring, drug-drug interactions, and pharmacogenetics.

Drug-resistant epilepsy — individualised perampanel dosing

PGx28 July 2026
4/10

Association of a CCB-Related Pharmacogenomics-Guided Strategy with Blood Pressure Outcomes and Short-Term Safety in Chinese Patients with Hypertension: A Secondary Exploratory Analysis of Two Randomized Cohorts.

Hypertension treated with calcium channel blockers

PGx11 August 2026

Frequently asked questions

Which drugs are affected by CYP3A5 in pharmacogenomics?+

tacrolimus — CPIC level A

How many Geno'X publications cover the CYP3A5 gene?+

7 publication(s) on CYP3A5 have been selected, summarised and scored by Geno'X on a public grading grid (domains: Pharmacogenomics).