CYP3A5
HGNC ↗7 article(s) in the watch · Pharmacogenomics
CYP3A5 influences the metabolism of tacrolimus, a narrow-therapeutic-index immunosuppressant. Expresser/non-expresser status (the *3 allele) determines the starting dose required to reach target concentrations (CPIC guidelines).
Drugs involved: tacrolimus
Recommendation: CPIC level A
Curated publications
Preemptive Pharmacogenetics in Renal Transplantation: A Real-World Assessment of Pharmacogenetic Actionability
Renal transplantation — preemptive pharmacogenetics
Integrating pharmacogenetic and clinical factors to predict the C0/D/W-based tacrolimus phenotype in kidney transplantation
Tacrolimus — pharmacogenetic prediction of pharmacokinetic phenotype (C0/D/W) in kidney transplantation by integrating CYP3A4/CYP3A5 variants and clinical factors
Effects of CYP3A4, CYP3A5, and ABCB1 genetic variants on tacrolimus metabolism during the early period after kidney transplantation
Kidney transplantation and tacrolimus exposure
A Review of Population Pharmacokinetic Models and Dosing Algorithms Assessing the Influence of CYP3A5 Genotype and Other Clinical Covariates on Tacrolimus Pharmacokinetics.
Organ transplantation — tacrolimus dosing
Population pharmacokinetics of tacrolimus and CYP3A5-driven variability: implications for model-informed dose individualization in pediatric renal transplant recipients.
Tacrolimus PK variability in pediatric renal transplantation
Toward individualized precision dosing of perampanel: Integrating therapeutic drug monitoring, drug-drug interactions, and pharmacogenetics.
Drug-resistant epilepsy — individualised perampanel dosing
Association of a CCB-Related Pharmacogenomics-Guided Strategy with Blood Pressure Outcomes and Short-Term Safety in Chinese Patients with Hypertension: A Secondary Exploratory Analysis of Two Randomized Cohorts.
Hypertension treated with calcium channel blockers
Frequently asked questions
Which drugs are affected by CYP3A5 in pharmacogenomics?+
tacrolimus — CPIC level A
How many Geno'X publications cover the CYP3A5 gene?+
7 publication(s) on CYP3A5 have been selected, summarised and scored by Geno'X on a public grading grid (domains: Pharmacogenomics).