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DICER1
HGNC ↗1 article(s) in the watch · Cancer genetics
DICER1 encodes a key microRNA-biogenesis enzyme. Germline variants cause DICER1 syndrome, a paediatric tumour predisposition.
InheritanceAutosomal dominant
Clinical spectrumPleuropulmonary blastoma, Sertoli-Leydig tumours, thyroid goitre/cancer, cystic nephroma
ManagementDedicated surveillance (chest, thyroid, pelvis) per paediatric protocols.