DICER1
HGNC ↗2 article(s) in the watch · Cancer genetics
DICER1 encodes a key microRNA-biogenesis enzyme. Germline variants cause DICER1 syndrome, a paediatric tumour predisposition.
Curated publications
DICER1 Syndrome and Tumor Pathology: An Updated Review for Diagnostic Practice.
DICER1 syndrome / tumor predisposition
The SINEs were there: identification of a pathogenic Alu insertion in a patient with DICER1-related tumour predisposition
*DICER1*-related tumour predisposition
Frequently asked questions
How is a DICER1-related condition inherited?+
Autosomal dominant
What is the clinical spectrum associated with DICER1?+
Pleuropulmonary blastoma, Sertoli-Leydig tumours, thyroid goitre/cancer, cystic nephroma
What is the management associated with DICER1?+
Dedicated surveillance (chest, thyroid, pelvis) per paediatric protocols.
How many Geno'X publications cover the DICER1 gene?+
2 publication(s) on DICER1 have been selected, summarised and scored by Geno'X on a public grading grid (domains: Cancer genetics).
