HLA-B
HGNC ↗6 article(s) in the watch · Pharmacogenomics
Specific HLA-B alleles predict severe drug hypersensitivity reactions: HLA-B*57:01 (abacavir), HLA-B*15:02 (carbamazepine, Stevens-Johnson syndrome) and HLA-B*58:01 (allopurinol). Pre-prescription screening is recommended (CPIC level A).
Drugs involved: abacavir (*57:01), carbamazepine / oxcarbazepine / phenytoin (*15:02), allopurinol (*58:01)
Recommendation: CPIC level A · RNPGx essential (abacavir)
Curated publications
HLA genotype testing for carbamazepine, oxcarbazepine and eslicarbazepine: A guideline developed by the UK Centre of Excellence in Regulatory Science and Innovation in Pharmacogenomics (CERSI-PGx)
Hypersensitivity to carbamazepine, oxcarbazepine and eslicarbazepine — *HLA* genotyping
Pharmacogenomics in epilepsy care across Asia
Epilepsy in Asia — pharmacogenomics of antiepileptic drugs (HLA-B*15:01, HLA-A*31:01, SCN1A/CYP2C19)
HLA-B 15:21 carrier status is a susceptibility factor of carbamazepine-induced nonimmediate cutaneous adverse reactions in HLA-B 15:02-negative patients: A retrospective cohort study.
Nonimmediate cutaneous adverse reactions to carbamazepine
Machine learning-based model for prediction of carbamazepine- and allopurinol-induced severe cutaneous adverse reactions in Vietnamese.
Carbamazepine- and allopurinol-induced severe cutaneous adverse reactions (SCARs)
Systematic review on genetic polymorphisms associated with idiosyncratic drug-induced liver injury (iDILI): iDILInet as an interactive visualization tool
Idiosyncratic drug-induced liver injury (iDILI) — genetic susceptibility
Pharmacogenomics of antibacterial and antiviral therapies: Clinical actionability, evidence gaps, and future directions.
Pharmacogenomics of anti-infective therapies
Frequently asked questions
Which drugs are affected by HLA-B in pharmacogenomics?+
abacavir (57:01), carbamazepine / oxcarbazepine / phenytoin (15:02), allopurinol (58:01) — CPIC level A · RNPGx essential (abacavir)
How many Geno'X publications cover the HLA-B gene?+
6 publication(s) on HLA-B have been selected, summarised and scored by Geno'X on a public grading grid (domains: Pharmacogenomics).
