HLA-B
HGNC ↗2 article(s) in the watch · Pharmacogenomics
Specific HLA-B alleles predict severe drug hypersensitivity reactions: HLA-B*57:01 (abacavir), HLA-B*15:02 (carbamazepine, Stevens-Johnson syndrome) and HLA-B*58:01 (allopurinol). Pre-prescription screening is recommended (CPIC level A).
Drugs involved: abacavir (*57:01), carbamazepine / oxcarbazepine / phenytoin (*15:02), allopurinol (*58:01)
Recommendation: CPIC level A · RNPGx essential (abacavir)
Curated publications
Pharmacogenomics in epilepsy care across Asia
Epilepsy in Asia — pharmacogenomics of antiepileptic drugs (HLA-B*15:01, HLA-A*31:01, SCN1A/CYP2C19)
Pharmacogenomics of antibacterial and antiviral therapies: Clinical actionability, evidence gaps, and future directions.
Pharmacogenomics of anti-infective therapies