← Gene index
LRRK2
HGNC ↗2 article(s) in the watch · Constitutional genetics
LRRK2 encodes a kinase whose gain-of-function variants (including G2019S) are a common cause of autosomal-dominant Parkinson disease with incomplete penetrance. Biallelic loss-of-function variants have also recently been associated with interstitial lung disease (emerging finding).
InheritanceDominant (Parkinson, incomplete penetrance); recessive for the emerging pulmonary phenotype
Clinical spectrumParkinson disease; interstitial lung disease in biallelic forms (emerging)
ManagementSymptomatic management; LRRK2 inhibitors in clinical development.
Curated publications
7/10
The Age at Onset of LRRK2 p.Gly2019Ser Parkinson's Disease Across Ancestries and Countries of Origin.
LRRK2 p.Gly2019Ser Parkinson's disease — age at onset by ancestry
Gén.3 June 2026
6/10Rare bi-allelic loss-of-function variants in the LRRK2 kinase cause interstitial lung disease
LRRK2 biallelic loss-of-function Mendelian interstitial lung disease
Gén.27 May 2026