MSH2
HGNC ↗4 article(s) in the watch · Cancer genetics
MSH2 belongs to the DNA mismatch-repair (MMR) system. Germline pathogenic MSH2 variants cause Lynch syndrome (HNPCC), an autosomal-dominant predisposition to colorectal, endometrial and other cancers.
Curated publications
Diverse mediators of cancer predisposition uncovered by germline whole genome sequencing of unexplained familial cancers.
Unexplained familial cancers without known pathogenic variant
WGS identifies Lynch syndrome (LS) patients and uncovers a large family with MSH2-related LS in Southern Thailand.
Lynch syndrome — hereditary colorectal and associated cancer predisposition linked to MMR genes
Lynch syndrome caused by a pathogenic SINE-VNTR-Alu (SVA) insertion in MSH2 gene identified by long-read DNA sequencing.
Lynch syndrome
Clinicopathologic Study of 39 Mismatch Repair-deficient Sarcomas Demonstrates Recurrent Histologic Patterns and Supports Universal Screening of Pleomorphic Rhabdomyosarcoma, Uterine Leiomyosarcoma, and Undifferentiated Sarcomas.
Lynch syndrome / MMR-deficient sarcomas
Frequently asked questions
How many Geno'X publications cover the MSH2 gene?+
4 publication(s) on MSH2 have been selected, summarised and scored by Geno'X on a public grading grid (domains: Cancer genetics).
