NUDT15
HGNC ↗2 article(s) in the watch · Pharmacogenomics
NUDT15 is involved in thiopurine metabolism. Its loss-of-function variants, common in East Asian populations, predispose to severe myelotoxicity; genotyping complements TPMT for dose adjustment (CPIC level A).
Drugs involved: thiopurines: azathioprine, 6-mercaptopurine, 6-thioguanine
Recommendation: CPIC level A
Curated publications
Comprehensive overview of the global pharmacogenetic and functional variability in NUDT15
Thiopurine toxicity (mercaptopurine, azathioprine, thioguanine) — severe myelotoxicity
6-Mercaptopurine metabolic profiles and clinical outcomes in TPMT and NUDT15 phenotypes during maintenance therapy for Thai paediatric acute lymphoblastic leukaemia
6-mercaptopurine — metabolic profiles and clinical toxicity by combined TPMT/NUDT15 phenotype in Thai pediatric ALL