NUDT15
HGNC ↗3 article(s) in the watch · Pharmacogenomics
NUDT15 is involved in thiopurine metabolism. Its loss-of-function variants, common in East Asian populations, predispose to severe myelotoxicity; genotyping complements TPMT for dose adjustment (CPIC level A).
Drugs involved: thiopurines: azathioprine, 6-mercaptopurine, 6-thioguanine
Recommendation: CPIC level A
Curated publications
Comprehensive overview of the global pharmacogenetic and functional variability in NUDT15
Thiopurine toxicity (mercaptopurine, azathioprine, thioguanine) — severe myelotoxicity
Pharmacogenetic Risk Factors for Thiopurine-Induced Leukopenia in Patients with Inflammatory Bowel Disease.
Thiopurine-induced leukopenia in inflammatory bowel disease
6-Mercaptopurine metabolic profiles and clinical outcomes in TPMT and NUDT15 phenotypes during maintenance therapy for Thai paediatric acute lymphoblastic leukaemia
6-mercaptopurine — metabolic profiles and clinical toxicity by combined TPMT/NUDT15 phenotype in Thai pediatric ALL
Frequently asked questions
Which drugs are affected by NUDT15 in pharmacogenomics?+
thiopurines: azathioprine, 6-mercaptopurine, 6-thioguanine — CPIC level A
How many Geno'X publications cover the NUDT15 gene?+
3 publication(s) on NUDT15 have been selected, summarised and scored by Geno'X on a public grading grid (domains: Pharmacogenomics).
