← Gene index
PALB2
HGNC ↗1 article(s) in the watch · Cancer genetics
PALB2 partners with BRCA2 in homologous recombination. Pathogenic variants confer a high breast-cancer risk and increased ovarian and pancreatic cancer risk.
InheritanceAutosomal dominant
Clinical spectrumBreast (high risk), ovary, pancreas
ManagementBRCA-like breast surveillance; discuss risk reduction; PARP-inhibitor sensitivity.
Curated publications
Frequently asked questions
How is a PALB2-related condition inherited?+
Autosomal dominant
What is the clinical spectrum associated with PALB2?+
Breast (high risk), ovary, pancreas
What is the management associated with PALB2?+
BRCA-like breast surveillance; discuss risk reduction; PARP-inhibitor sensitivity.
How many Geno'X publications cover the PALB2 gene?+
1 publication(s) on PALB2 have been selected, summarised and scored by Geno'X on a public grading grid (domains: Cancer genetics).
