← Gene index
PALB2
HGNC ↗1 article(s) in the watch · Cancer genetics
PALB2 partners with BRCA2 in homologous recombination. Pathogenic variants confer a high breast-cancer risk and increased ovarian and pancreatic cancer risk.
InheritanceAutosomal dominant
Clinical spectrumBreast (high risk), ovary, pancreas
ManagementBRCA-like breast surveillance; discuss risk reduction; PARP-inhibitor sensitivity.