PALB2
HGNC ↗2 article(s) in the watch · Cancer genetics
PALB2 partners with BRCA2 in homologous recombination. Pathogenic variants confer a high breast-cancer risk and increased ovarian and pancreatic cancer risk.
Curated publications
Genomic Landscape of 6597 Hong Kong HBOC Patients: Implications for Beyond-BRCA Multi-Gene Panel Testing and Cancer Surveillance.
Hereditary breast and ovarian cancer predisposition
Differential causative effects of germline pathogenic variants in MUTYH and PALB2 in a patient with colorectal polyposis and breast cancer
MINAS (Multi-locus Inherited Neoplasia Allele Syndrome) — biallelic MUTYH + heterozygous PALB2
Frequently asked questions
How is a PALB2-related condition inherited?+
Autosomal dominant
What is the clinical spectrum associated with PALB2?+
Breast (high risk), ovary, pancreas
What is the management associated with PALB2?+
BRCA-like breast surveillance; discuss risk reduction; PARP-inhibitor sensitivity.
How many Geno'X publications cover the PALB2 gene?+
2 publication(s) on PALB2 have been selected, summarised and scored by Geno'X on a public grading grid (domains: Cancer genetics).