RB1

1 article(s) in the watch · Cancer genetics

RB1 is the prototypical tumour-suppressor gene. Germline variants cause heritable retinoblastoma and a risk of second cancers.

InheritanceAutosomal dominant

Clinical spectrumRetinoblastoma, osteosarcoma and other second cancers

ManagementEarly infant ophthalmological screening; second-tumour surveillance.

Curated publications

Spectrum of Germline Cytogenomic Alterations in RB1 in Mexican Patients With Retinoblastoma.

Retinoblastoma — germline RB1 cytogenomic spectrum in Mexican patients