← Gene index
SLCO1B1
HGNC ↗1 article(s) in the watch · Pharmacogenomics
SLCO1B1 encodes the hepatic organic-anion transporter OATP1B1, involved in statin uptake. The c.521T>C (*5) variant increases the risk of statin-associated myopathy, particularly with simvastatin (CPIC guidelines).
PharmacogenomicsLevel APharmGKB 1A
Drugs involved: statins (notably simvastatin) — myopathy risk
Recommendation: CPIC level A