TP53

The biology of hypomorphic TP53 variants and implications for clinical management.

Li-Fraumeni syndrome / hypomorphic TP53 variants

Performance of LFSPRO prediction in TP53 mutation status for prospectively collected probands.

Li-Fraumeni syndrome (LFS) — TP53 hereditary multi-cancer predisposition

A zero-parameter framework for accurate TP53 missense variant functional classification.

TP53 missense variant functional classification / Li-Fraumeni syndrome

A zero-parameter first-principles gate framework for full-length TP53 missense variant interpretation

Classification of *TP53* missense variants — first-principles approach

Clinical and surveillance outcomes of the TP53 c.1000G > C (p.Gly334Arg) variant.

Attenuated Li-Fraumeni syndrome — TP53 p.Gly334Arg variant

Surveillance adherence and clinical findings in children with confirmed or familial TP53 variants: the Swedish multicenter constitutional TP53 study (SWEP53).

Li-Fraumeni syndrome

European Colonial Echoes in Cancer Risk: Lessons from the TP53 p.R337H Founder Variant in Brazil

Li-Fraumeni syndrome (attenuated) — pan-cancer predisposition

Interpreting TP53 pathogenic variants: diagnostic complexities of mosaic and germline variants.

Li-Fraumeni syndrome / mosaic TP53 variants

Genotypic and phenotypic characteristics of germline TP53 variant carriers: experience from two cancer genetic counseling units.

Li-Fraumeni syndrome

Missense but mis-spliced: germline TP53 variant c.671A > C (p.E224A) and the path from uncertainty to pathogenicity.

Li-Fraumeni syndrome

Proton therapy in young breast cancer patients with germline TP53 and ATM mutations: a case series.

Breast cancer — proton therapy in carriers of germline TP53 and ATM mutations

Clinical characteristics and management of Li-Fraumeni syndrome-associated lung cancer.

Lung adenocarcinoma in Li-Fraumeni syndrome