TPMT
HGNC ↗3 article(s) in the watch · Pharmacogenomics
TPMT encodes thiopurine S-methyltransferase, which detoxifies thiopurines (azathioprine, 6-mercaptopurine). Deficiency exposes patients to severe myelotoxicity; genotyping, together with NUDT15, guides dose adjustment (CPIC level A).
Drugs involved: thiopurines: azathioprine, 6-mercaptopurine, 6-thioguanine
Recommendation: CPIC level A · RNPGx "essential"
Curated publications
Clinical Functional Assignment of TPMT and NUDT15 Alleles by the Clinical Pharmacogenetics Implementation Consortium Pharmacogene Curation Expert Panel.
Thiopurine toxicity and dose adjustment
The decline of 6-thioguanine nucleotides is not linked to impaired efficacy or safety of thiopurines in pregnant women with inflammatory bowel disease
Thiopurines during pregnancy — inflammatory bowel disease
Therapeutic Drug Monitoring and Pharmacogenomics of Thiopurines in Inflammatory Bowel Disease: International Guidelines Revisited.
IBD — thiopurine monitoring, TPMT/NUDT15 PGx and therapeutic drug monitoring
Frequently asked questions
Which drugs are affected by TPMT in pharmacogenomics?+
thiopurines: azathioprine, 6-mercaptopurine, 6-thioguanine — CPIC level A · RNPGx "essential"
How many Geno'X publications cover the TPMT gene?+
3 publication(s) on TPMT have been selected, summarised and scored by Geno'X on a public grading grid (domains: Pharmacogenomics).
