← Gene index
TPMT
HGNC ↗1 article(s) in the watch · Pharmacogenomics
TPMT encodes thiopurine S-methyltransferase, which detoxifies thiopurines (azathioprine, 6-mercaptopurine). Deficiency exposes patients to severe myelotoxicity; genotyping, together with NUDT15, guides dose adjustment (CPIC level A).
PharmacogenomicsLevel APharmGKB 1A
Drugs involved: thiopurines: azathioprine, 6-mercaptopurine, 6-thioguanine
Recommendation: CPIC level A · RNPGx "essential"