VKORC1
HGNC ↗2 article(s) in the watch · Pharmacogenomics
VKORC1 is the target of vitamin-K antagonists. Together with CYP2C9, its genotype explains a substantial part of the interindividual variability in warfarin dosing and informs dosing algorithms (CPIC guidelines).
Drugs involved: warfarin and vitamin-K antagonists
Recommendation: CPIC level A (with CYP2C9)
Curated publications
Derivation and Validation of a Genotype-Guided Warfarin Dosing Model in a Mixed Arab Population.
Warfarin anticoagulation / interindividual variability
Limitations of VKORC1 rs9934438 as a Surrogate Marker for Vitamin K Antagonist Dose Adjustment.
Vitamin K antagonist dosing
Frequently asked questions
Which drugs are affected by VKORC1 in pharmacogenomics?+
warfarin and vitamin-K antagonists — CPIC level A (with CYP2C9)
How many Geno'X publications cover the VKORC1 gene?+
2 publication(s) on VKORC1 have been selected, summarised and scored by Geno'X on a public grading grid (domains: Pharmacogenomics).