The Costs of Genomic Newborn Screening in England: A Micro-Costing Analysis from the Generation Study.

Time-driven activity-based costing (TDABC) micro-costing analysis of genomic newborn screening delivery across 6 English NHS Trusts

This micro-costing analysis estimates the cost of delivering genomic newborn screening (gNBS) at £1,208 per newborn in the Generation Study in England, using a TDABC approach across 6 NHS Trusts. Sequencing accounts for 58% of total costs (mainly consumables). Excluding research-specific activities, the cost falls to £963, reflecting routine clinical delivery. These data are essential for future cost-effectiveness analyses supporting a national implementation decision.

Synthesis written by Geno'X. For the full original abstract, please refer to the source publication.

The cost of £963 per newborn in routine conditions is a key reference figure for discussions on national implementation in England and beyond. The predominant share of sequencing highlights that future decreases in sequencing costs will transform the economic equation. These data usefully complement the Generation Study clinical outcomes published separately.

Clinical impact: 2/3 · Evidence strength: 2/3 · Novelty: 1/2 · Sample size: 0/1 · Journal quality: 1/1 → Total: 6/10