HIPK4 is a novel gene associated with teratozoospermia

HIPK4 (rare variants — candidate new gene)

Functional validation (spermatogenesis, spermatozoon morphology)

Proposal of HIPK4 as a new teratozoospermia gene, based on the identification of rare variants in patients with spermatozoon morphological abnormalities, complemented by functional analysis of HIPK4's role in spermatogenesis.

Synthesis written by Geno'X. For the full original abstract, please refer to the source publication.

To be added to teratozoospermia panels. Relevant functional validation but limited cohort size — to watch for consolidated publication.

new gene +3; functional analysis +2; limited cohort +0; preprint −1; panel impact +1; infertility-specific +2