Cancer genetics

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Cancer genetics

Week of 7 July 2026

7 articles

Geno'X Veille — genox-veille.fr

Key takeaways this week

►HBOC — multi-omics reveals susceptibility factors in the 80% of BRCA-negative patients.
►CDH1 — 15 years of surveillance: endoscopy misses about a third of signet ring cell carcinomas.
►TP53 — the sperm-donor case revives the question of germline mosaicism in cancer genetics.

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Autosomal dominantPubMed

Multi-omics analysis in suspected hereditary breast and ovarian cancer cases reveals novel candidate susceptibility factors.

Hereditary breast and ovarian cancer (HBOC)

NPJ Breast Cancer 2026· JulRead

Hereditary lung cancer predisposition

Autosomal dominantPubMed

Germline Mutations as Risk Factors for Lung Cancer: A Systematic Review and Meta-analysis.

Hereditary lung cancer predisposition

J Thorac Oncol 2026· JulRead

Autosomal dominantPubMed

Functional characterization of BRCA2 variants of uncertain significance identified in Korean breast cancer patients.

Hereditary breast cancer (BRCA2 variants of uncertain significance)

Breast cancerFunctional SNVVUS reclassified

Breast Cancer 2026· JulRead

Germline predisposition

Autosomal dominantPubMed

Hereditary Cancer Genetic Testing for All? A Retrospective Analysis on Genetic Mutations Found in Individuals Not Meeting NCCN® Guidelines.

Hereditary cancers (expanded testing beyond NCCN criteria)

Germline predispositionMainstreaming

Eur J Breast Health 2026· JunRead

Autosomal dominantPubMed

Endoscopic detection of signet ring cell carcinoma in CDH1 carriers: a 15-year single-centre experience.

Hereditary diffuse gastric cancer (CDH1 carriers)

Gastric cancerProphylactic surgery

Fam Cancer 2026· JulRead

Autosomal dominantPubMed

Choroidal melanoma and polydactylous onychopapilloma leading to diagnosis of BAP1 tumor predisposition syndrome.

BAP1 tumor predisposition syndrome (BAP1-TPDS)

Ophthalmic Genet 2026· JulRead

Germline and somatic mosaicism (implications for cancer genetics)

From curiosity to clinical relevance: Rethinking genetic mosaicism.

Germline and somatic mosaicism (implications for cancer genetics)

J Am Assoc Nurse Pract 2026· JulRead

References and sources

Hereditary breast and ovarian cancer (HBOC). NPJ Breast Cancer 2026. PMID 42380125. Score 10/10. https://pubmed.ncbi.nlm.nih.gov/42380125/
Hereditary lung cancer predisposition. J Thorac Oncol 2026. PMID 42409116. Score 8/10. https://pubmed.ncbi.nlm.nih.gov/42409116/
BRCA2 — Hereditary breast cancer (BRCA2 variants of uncertain significance). Breast Cancer 2026. PMID 42400768. Score 8/10. https://pubmed.ncbi.nlm.nih.gov/42400768/
Hereditary cancers (expanded testing beyond NCCN criteria). Eur J Breast Health 2026. PMID 42317085. Score 8/10. https://pubmed.ncbi.nlm.nih.gov/42317085/
CDH1 — Hereditary diffuse gastric cancer (CDH1 carriers). Fam Cancer 2026. PMID 42406170. Score 6/10. https://pubmed.ncbi.nlm.nih.gov/42406170/
Germline and somatic mosaicism (implications for cancer genetics). J Am Assoc Nurse Pract 2026. PMID 42383591. Score 5/10. https://pubmed.ncbi.nlm.nih.gov/42383591/
BAP1 — BAP1 tumor predisposition syndrome (BAP1-TPDS). Ophthalmic Genet 2026. PMID 42394126. Score 6/10. https://pubmed.ncbi.nlm.nih.gov/42394126/