Radiation therapy management in BRCA1/2 carriers diagnosed with early breast cancer: An international cohort study.

Survival and recurrence comparison between BCS+RT, mastectomy alone, or mastectomy+RT in the international BCY cohort

The international BRCA BCY cohort (NCT03673306) includes women ≤40 years with invasive breast cancer and confirmed germline BRCA1/2 variants treated between 2000 and 2020. Overall survival and recurrence-free intervals are compared between BCS+RT, mastectomy alone, and mastectomy+RT. These real-world data address a critical gap on the oncological safety of breast conservation in young BRCA carriers, for whom mastectomy is often preferred without robust comparative evidence.

Synthesis written by Geno'X. For the full original abstract, please refer to the source publication.

The question of breast-conserving surgery in young BRCA carriers remains one of the most frequent debates in oncogenetics consultations. This well-conducted international cohort finally provides comparative real-world data — a concrete clinical contribution to support patient counseling on surgical choices.

Clinical impact: 2/3 · Evidence strength: 2/3 · Novelty: 1/2 · Sample size: 1/1 · Publication status: 1/1 → Total: 7/10