Impact of Ethnicity on the Uptake of Risk Reducing Mastectomy in Unaffected BRCA1/2 and PALB2 Carriers in Canada.

Retrospective multicentre cohort (Montreal): predictors of risk-reducing mastectomy uptake by self-reported ethnicity

476 unaffected carriers of germline BRCA1/2 or PALB2 variants were included, with 43.1% undergoing risk-reducing mastectomy. Significant disparities in uptake by self-reported ethnicity are observed. These data highlight the importance of culturally adapted oncogenetics consultations to offer equitable management to carriers of all backgrounds.

Synthesis written by Geno'X. For the full original abstract, please refer to the source publication.

Uptake of prophylactic surgery varies considerably by cultural background — a point systematically underestimated in French oncogenetics consultations, which remain largely monocultural. This Canadian cohort provides concrete data to adapt counseling practices.

Clinical impact: 2/3 · Evidence strength: 2/3 · Novelty: 1/2 · Sample size: 1/1 · Publication status: 0/1 → Total: 6/10