Histologic Spectrum of BRCA-Associated Pancreatic Ductal Adenocarcinoma: A Descriptive Morphologic Study

Histological characterization of the morphological spectrum of germline *BRCA1/2* pancreatic ductal adenocarcinoma

A descriptive morphological study characterizes the histological spectrum of pancreatic ductal adenocarcinomas (PDAC) associated with germline BRCA1 or BRCA2 mutations. These homologous recombination repair-deficient cancers represent a molecularly defined subgroup with potential for PARP inhibitor response. Fine histological characterization of this subgroup contributes to understanding morphological features that could guide constitutional genetic testing in anatomopathological practice.

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The question of guiding constitutional genetic testing from morphological features of PDAC is practically important for pathologists and oncogeneticists. If histological features specific to BRCA-PDAC are confirmed, this could constitute a new criterion for referral to oncogenetics consultation.