UGT1A1
HGNC ↗2 article(s) in the watch · Pharmacogenomics
UGT1A1 encodes a glucuronidation enzyme central to the clearance of bilirubin and many drugs. Its variants (notably the UGT1A1*28 allele) underlie Gilbert syndrome and modulate the toxicity of drugs such as irinotecan (pharmacogenetic guidelines).
Drugs involved: irinotecan; atazanavir
Recommendation: Irinotecan: RNPGx "essential", FDA/DPWG (no dedicated CPIC guideline). Atazanavir: CPIC level A.
Curated publications
Real-World Impact of UGT1A1 Genotype-Guided Irinotecan Dosing on Severe Toxicity and Hospitalization: A Multicenter Study.
Severe irinotecan toxicity in UGT1A1 poor metabolizers
Concentration dependency of an acyl glucuronide metabolite in eltrombopag-induced hepatotoxicity: Role of UGT1A1 genotype
Eltrombopag-induced hepatotoxicity (thrombopoietin receptor agonist) — role of UGT1A1 genotype