UGT1A1
HGNC ↗6 article(s) in the watch · Pharmacogenomics
UGT1A1 encodes a glucuronidation enzyme central to the clearance of bilirubin and many drugs. Its variants (notably the UGT1A1*28 allele) underlie Gilbert syndrome and modulate the toxicity of drugs such as irinotecan (pharmacogenetic guidelines).
Drugs involved: irinotecan; atazanavir
Recommendation: Irinotecan: RNPGx "essential", FDA/DPWG (no dedicated CPIC guideline). Atazanavir: CPIC level A.
Curated publications
Real-World Impact of UGT1A1 Genotype-Guided Irinotecan Dosing on Severe Toxicity and Hospitalization: A Multicenter Study.
Severe irinotecan toxicity in UGT1A1 poor metabolizers
UGT1A1 genotype testing for irinotecan: A guideline developed by the UK Centre of Excellence in Regulatory Science and Innovation in Pharmacogenomics (CERSI-PGx).
Irinotecan pharmacogenetics (UGT1A1)
Pharmacogenomics of dolutegravir: A scoping review of evidence, gaps and clinical implications.
HIV infection treated with dolutegravir
Concentration dependency of an acyl glucuronide metabolite in eltrombopag-induced hepatotoxicity: Role of UGT1A1 genotype
Eltrombopag-induced hepatotoxicity (thrombopoietin receptor agonist) — role of UGT1A1 genotype
UGT1A1 and irinotecan: Ready for routine pharmacogenetic care
Irinotecan toxicity (chemotherapy)
A single-arm phase II trial of UGT1A1 genotype-guided high-dose irinotecan rechallenge in refractory metastatic colorectal cancer.
Refractory metastatic colorectal cancer
Frequently asked questions
Which drugs are affected by UGT1A1 in pharmacogenomics?+
irinotecan; atazanavir — Irinotecan: RNPGx "essential", FDA/DPWG (no dedicated CPIC guideline). Atazanavir: CPIC level A.
How many Geno'X publications cover the UGT1A1 gene?+
6 publication(s) on UGT1A1 have been selected, summarised and scored by Geno'X on a public grading grid (domains: Pharmacogenomics).
