UGT1A1
HGNC ↗8 article(s) in the watch · Pharmacogenomics
UGT1A1 encodes a glucuronidation enzyme central to the clearance of bilirubin and many drugs. Its variants (notably the UGT1A1*28 allele) underlie Gilbert syndrome and modulate the toxicity of drugs such as irinotecan (pharmacogenetic guidelines).
Drugs involved: irinotecan; atazanavir
Recommendation: Irinotecan: RNPGx "essential", FDA/DPWG (no dedicated CPIC guideline). Atazanavir: CPIC level A.
Curated publications
Real-World Impact of UGT1A1 Genotype-Guided Irinotecan Dosing on Severe Toxicity and Hospitalization: A Multicenter Study.
Severe irinotecan toxicity in UGT1A1 poor metabolizers
UGT1A1 genotype testing for irinotecan: A guideline developed by the UK Centre of Excellence in Regulatory Science and Innovation in Pharmacogenomics (CERSI-PGx).
Irinotecan pharmacogenetics (UGT1A1)
Pharmacogenomics of dolutegravir: A scoping review of evidence, gaps and clinical implications.
HIV infection treated with dolutegravir
Concentration dependency of an acyl glucuronide metabolite in eltrombopag-induced hepatotoxicity: Role of UGT1A1 genotype
Eltrombopag-induced hepatotoxicity (thrombopoietin receptor agonist) — role of UGT1A1 genotype
Gene-dose interaction in low-dose irinotecan: a real-world cohort study of the association between adverse effects and UGT1A1 polymorphism
Irinotecan toxicity in patients treated for cancer
UGT1A1 gene polymorphisms and their impact on plasma trough concentrations of dolutegravir in Chinese adults with human immunodeficiency virus-1 infection.
HIV-1 infection treated with dolutegravir
UGT1A1 and irinotecan: Ready for routine pharmacogenetic care
Irinotecan toxicity (chemotherapy)
A single-arm phase II trial of UGT1A1 genotype-guided high-dose irinotecan rechallenge in refractory metastatic colorectal cancer.
Refractory metastatic colorectal cancer
Frequently asked questions
Which drugs are affected by UGT1A1 in pharmacogenomics?+
irinotecan; atazanavir — Irinotecan: RNPGx "essential", FDA/DPWG (no dedicated CPIC guideline). Atazanavir: CPIC level A.
How many Geno'X publications cover the UGT1A1 gene?+
8 publication(s) on UGT1A1 have been selected, summarised and scored by Geno'X on a public grading grid (domains: Pharmacogenomics).