Occult invasive and preneoplastic lesions at risk-reducing salpingo-oophorectomy in BRCA1/2 carriers: A multicenter retrospective cohort study

Prevalence and spectrum of occult invasive or preneoplastic lesions detected at RRSO in *BRCA1/2* carriers

A multicenter retrospective study of 291 BRCA1/2-carrying women undergoing risk-reducing salpingo-oophorectomy (RRSO) characterizes the prevalence and spectrum of occult invasive or preneoplastic lesions discovered intraoperatively. These data document the concrete benefit of prophylactic surgery through detection of early asymptomatic lesions. Recurrent BRCA variants in the regional cohort are also described, contributing to local epidemiological characterization.

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These real-world cohort data strengthen the case for RRSO in BRCA1/2 carriers by quantifying the risk of asymptomatic occult lesions. The variability between BRCA1 and BRCA2 in lesion prevalence and type is important for genetic counseling and surgical timing decisions.