Lynch Syndrome and Ethnicity: Disparities in Prevalence, Affected Genes, Cancer Spectrum and Screening

Ethnic disparities in Lynch syndrome prevalence, affected MMR genes, cancer spectrum, and screening practices

A systematic review analyzes ethnic disparities in Lynch syndrome in terms of prevalence, affected MMR genes, cancer spectrum, and universal screening practices. Data document significant differences between populations, with varying gene profiles and tumor spectra by ancestry. These disparities have direct implications for adapting screening criteria and genetic testing panels to different populations.

Synthesis written by Geno'X. For the full original abstract, please refer to the source publication.

The issue of ethnic disparities in Lynch syndrome is fundamental for equity in cancer genetics. The fact that affected genes and tumor spectrum vary by ancestry raises the question of personalizing surveillance protocols — an increasing challenge in French consultations with an increasingly diverse population.