Characterizing Breast Cancer Prevalence Among Female SDHx Pathogenic Variant Carriers in a Laboratory Research Registry

Breast cancer prevalence in *SDHx* (SDHA, SDHB, SDHC, SDHD) pathogenic variant carriers

A laboratory registry study characterizes breast cancer prevalence in women carrying pathogenic variants in SDHx genes (SDHA, SDHB, SDHC, SDHD), primarily known for paraganglioma and pheochromocytoma predisposition. These data explore the potential expansion of the tumor spectrum of hereditary SDHx syndromes to breast cancer, an association still insufficiently documented to modify current surveillance recommendations.

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The SDHx-breast cancer association is emerging and warrants attention, but registry data remain insufficient to modify current surveillance recommendations. These results justify a larger prospective study. Worth monitoring for oncogeneticists managing SDHx families with breast cancer history.