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Pharmacogenomics
Week of 27 May 2026
5 articles
Geno'X Veille — genox-veille.fr
Key takeaways this week
- ►CYP2C19/CYP2D6 — preemptive genotyping significantly reduces antidepressant discontinuation in a cohort of 5,800 patients.
- ►DPYD — genotyping before fluoropyrimidines is cost-saving and generates more QALYs: economic confirmation in NHS Wales.
- ►CYP2D6 — 12 novel alleles functionally characterized in the Chinese Han population, enriching PharmVar databases.
5 articles of 5
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CYP2C19
PubMedGenotype influences antidepressant discontinuation in a pre-emptive pharmacogenetic testing population.
Depression / Anxiety
7
Preemptive genotypingAdverse reaction
Pharmacogenomics J 2026· MayRead
Pharmacogenetics in intensive care
PubMedImpact of population-specific pharmacogenomic variants on drug dosing in ICU patients.
Pharmacogenetics in intensive care
7
Preemptive genotypingDose recommendation
Pharmacogenomics J 2026· MayRead
CYP2D6
PubMedIdentification and drug metabolic activity evaluation of 12 CYP2D6 allelic variants newly detected in the Chinese population.
Pharmacogenetics — drug metabolism
7
Recurrent variantNew interaction
Gene 2026· MayRead
DPYD
PubMedCost-effectiveness of DPYD genotyping prior to fluoropyrimidine-based treatment for colorectal cancer in Wales.
Colorectal cancer — fluoropyrimidine toxicity
7
OncologyCPIC Level ADose recommendation
Br J Clin Pharmacol 2026· MayRead
CYP2C19
PubMedVoriconazole therapy and CYP2C19 phenotype: identifying patients who may need alternative antifungal therapy.
Invasive fungal infections — voriconazole
6
Adverse reactionDose recommendation
J Antimicrob Chemother 2026· MayRead
References and sources
- CYP2C19 — Depression / Anxiety. Pharmacogenomics J 2026. PMID 42168153. Score 7/10. https://pubmed.ncbi.nlm.nih.gov/42168153/
- Pharmacogenetics in intensive care. Pharmacogenomics J 2026. PMID 42168146. Score 7/10. https://pubmed.ncbi.nlm.nih.gov/42168146/
- CYP2D6 — Pharmacogenetics — drug metabolism. Gene 2026. PMID 41806934. Score 7/10. https://pubmed.ncbi.nlm.nih.gov/41806934/
- CYP2C19 — Invasive fungal infections — voriconazole. J Antimicrob Chemother 2026. PMID 42153394. Score 6/10. https://pubmed.ncbi.nlm.nih.gov/42153394/
- DPYD — Colorectal cancer — fluoropyrimidine toxicity. Br J Clin Pharmacol 2026. PMID 42171466. Score 7/10. https://pubmed.ncbi.nlm.nih.gov/42171466/
