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ACKR1
Autosomique récessifPubMed★ Top pick
ACKR1/Duffy-null genotype testing for clozapine: A guideline developed by the UK Centre of Excellence in Regulatory Science and Innovation in Pharmacogenomics (CERSI-PGx).
ACKR1/Duffy-null associated neutropenia (ADAN) in clozapine-treated patients
9
/10
New recommendationAdverse reaction
British Journal of Clinical Pharmacology 2026· MayRead
CYP2C19
PubMed★ Top pick
Sex Differences in Prognostic Implications of CYP2C19 Genotype After Drug-Eluting Stent Implantation.
Acute coronary syndrome on clopidogrel — CYP2C19 genotype prognostic effect differs by sex
9
/10
CardiologyRecurrent variantDose recommendation
J Am Heart Assoc 2026· MayRead
DPYD
PubMed★ Top pick
Integrating Somatic and Germline Pharmacogenomics for Therapeutic Decisions in Precision Oncology.
Pharmacogenomics in precision oncology — somatic + germline integration in 10,302 cancer patients (TCGA)
9
/10
OncologyPreemptive genotypingCPIC Level A
JCO Precis Oncol 2026· MayRead
DPYD
PubMed★ Top pick
Importance of and Strategies for Implementing DPYD Testing to Prevent Severe Fluoropyrimidine Chemotherapy Toxicity
Severe fluoropyrimidine toxicity (5-FU, capecitabine, tegafur) — neutropenia, severe mucositis, death
9
/10
OncologyCPIC Level ANew recommendation
ASCO Educational Book, 2026· AprRead
CYP2C19
PubMedImpact of CYP2C19 and CYP3A4 Inhibitor Use on Clopidogrel Clinical Effectiveness in CYP2C19 Genotyped Patients Undergoing Percutaneous Coronary Intervention.
CYP2C19 phenoconversion under drug inhibitors after percutaneous coronary intervention
8
/10
CardiologyPhénoconversionAdverse reaction
Clinical Pharmacology and Therapeutics 2026· MayRead
FTO
PubMedFTO rs7195994 Is associated with TNF inhibitor response in lean rheumatoid arthritis patients: A BMI-stratified pharmacogenetic analysis.
Rheumatoid arthritis — TNF inhibitor non-response according to FTO genotype and BMI
8
/10
New interactionRecurrent variant
Pharmacogenomics J 2026· MayRead
CYP2D6
PubMedEffect of Individual and Combined Cytochrome P450 Activity Scores on Symptom Improvement and Side Effects in Youth Treated With Sertraline.
Pediatric mental health conditions treated with sertraline — side effects and symptom improvement by CYP450 genotype
8
/10
PhénoconversionDose recommendation
Clin Transl Sci 2026· MayRead
Journal
Uncovering Coenzyme Q10-Related Genetic Determinants of Statin-Associated Muscle Symptoms: Evidence from the UK Biobank and the All of Us Research Program
Statin-associated muscle symptoms (SAMS) — genetic determinants related to the coenzyme Q10 pathway
8
/10
Adverse reactionNew interaction
Clin Pharmacol Ther 2026· MayRead
CYP2D6
JournalFrequency of Key Pharmacogenes CYP2C9, CYP2C19, CYP2D6, and SLCO1B1 in the Yogyakarta Population: Implications for Precision Prescribing in Indonesia
PGx allele frequencies (CYP2C9, CYP2C19, CYP2D6, SLCO1B1) in the Yogyakarta population (Indonesia)
8
/10
DiabetesRecurrent variantPreemptive genotyping
Clin Pharmacol Ther 2026· AprRead
APOE
JournalAPOE genotype and the effect of statins on lipid outcomes: A meta-analysis
Lipid response to statins by APOE genotype — meta-analysis
8
/10
Recurrent variantDose recommendation
Br J Clin Pharmacol 2026· AprRead
CYP2C19
PubMedGenotype-Guided vs Conventional Oral P2Y12 Inhibitors in Acute Coronary Syndrome: A Combined Analysis
Acute coronary syndrome (ACS) — MACE risk under clopidogrel
8
/10
CardiologyCPIC Level ADose recommendation
JACC: Cardiovascular Interventions, 2026· FebRead
CYP2D6
PubMedEconomic effectiveness of pharmacogenomics-guided prescribing for psychiatric disorders: a systematic review and meta-analysis
Psychiatric disorders — economic efficiency of PGx genotyping
8
/10
PsychiatryCPIC Level APreemptive genotyping
The Pharmacogenomics Journal, 2026· AprRead
CYP2C19
PubMedCYP2C19 genotype-guided antiplatelet therapy to prevent thromboembolic events after stent-assisted coil embolization of unruptured intracranial aneurysms: a retrospective cohort study.
Unruptured intracranial aneurysm treated by stent-assisted coil embolization
7
/10
CardiologyDose recommendationAdverse reaction
Journal of Neurointerventional Surgery 2026· MayRead
SLCO1B1
PubMedBiomarker-Based Prediction of OATP1B1 Activity in Clinical Routine — Investigating Coproporphyrins as Markers for Drug-Drug-Gene Interactions.
SLCO1B1 phenoconversion in clinical routine: detection by endogenous biomarker
7
/10
DiabetesPhénoconversionNew interaction
Clinical Pharmacology and Therapeutics 2026· MayRead
CYP2C19
PubMedLimited Visibility and Perception of the Clinical Relevance of Clopidogrel Pharmacogenetics in Cardiology Literature.
Under-implementation of clopidogrel pharmacogenetics in cardiology
7
/10
CardiologyNew recommendationRecurrent variant
Clin Transl Sci 2026· MayRead
CYP2C19
PubMedPharmacogenomic Profiling of Voriconazole Enables Predicting Its Toxicity in Pediatric Leukemia and Hematopoietic Stem Cell Transplant Recipients.
Voriconazole toxicity in pediatric leukemia and HSCT — prediction by CYP2C19 genotype
7
/10
Adverse reactionDose recommendation
J Clin Pharmacol 2026· MayRead
UGT1A1
JournalConcentration dependency of an acyl glucuronide metabolite in eltrombopag-induced hepatotoxicity: Role of UGT1A1 genotype
Eltrombopag-induced hepatotoxicity (thrombopoietin receptor agonist) — role of UGT1A1 genotype
7
/10
Adverse reactionNew interaction
Br J Clin Pharmacol 2026· AprRead
HLA-B
PubMedPharmacogenomics in epilepsy care across Asia
Epilepsy in Asia — pharmacogenomics of antiepileptic drugs (HLA-B*15:01, HLA-A*31:01, SCN1A/CYP2C19)
7
/10
CPIC Level AAdverse reaction
Epilepsia 2026· MayRead
NUDT15
PubMedComprehensive overview of the global pharmacogenetic and functional variability in NUDT15
Thiopurine toxicity (mercaptopurine, azathioprine, thioguanine) — severe myelotoxicity
7
/10
ImmunosuppressantsCPIC Level AAdverse reaction
Human Genomics, 2026· AprRead
CYP2C19
PubMedInfluence of combined CYP2C19 and CYP2D6 phenotypes on adverse drug reactions in patients with major depressive disorder: a clinical cohort study
Major depressive disorder (MDD) — antidepressant adverse drug reactions
7
/10
PsychiatryCPIC Level APhénoconversion
The Pharmacogenomics Journal, 2026· AprRead
CYP2D6
PubMedA pilot study of pharmacogenomic testing as a tool to enhance depression care in Veterans
Depression in military veterans — implementation of multigene PGx genotyping
7
/10
PsychiatryCPIC Level APreemptive genotyping
The Pharmacogenomics Journal, 2026· AprRead
CYP2C19
PubMedIdentification and functional characterization of 11 novel CYP2C19 variants in the Chinese Han population
CYP2C19 metabolic variability — new alleles in Chinese Han population
7
/10
New interactionRecurrent variant
Pharmacogenomics, 2025· DecRead
CYP2D6
PubMedAnalytical Validation of an Annotation Tool for WGS-Based Pharmacogenomics: Preparing for Clinical Implementation
Clinical implementation of WGS for pharmacogenetics — analytical validation
7
/10
Preemptive genotyping
Clinical and Translational Science, 2026· AprRead
CYP2C19
PubMedChallenges and prospects of CYP2C19 genotype-guided clopidogrel therapy from the perspective of precision medicine
Post-PCI antiplatelet therapy — debate on CYP2C19 genotyping generalization
7
/10
CardiologyCPIC Level ADose recommendation
Frontiers in Pharmacology, 2026Read
CYP2C9
PubMedDrug-gene interactions and the risk of diabetic microvascular complications: A population-based cohort study
Diabetic microvascular complications — influence of drug-gene interactions on risk
7
/10
DiabetesAdverse reactionNew interaction
Diabetes, Obesity and Metabolism, 2026· AprRead
DPYD
PubMedDihydropyrimidine dehydrogenase (DPYD) genetic testing and treatment with 5-fluoropyrimidines in cancer patients
Cancer — prevention of 5-fluoropyrimidine toxicity
7
/10
OncologyCPIC Level ANew recommendation
Pharmacogenomics, 2026Read
CYP2D6
PubMedPharmacogenetic Variability and Quality of Life in Adolescent Patients with Schizophrenia: The Impact of Metabolizer Status, Symptom Severity, and Adverse Reactions to Antipsychotic Treatment
CYP2D6 PGx variability and antipsychotic tolerability in adolescent schizophrenia patients
7
/10
PsychiatryCPIC Level AAdverse reaction
Journal of Clinical Medicine, 2026· AprRead
Week of 20 May 2026
4 articles
ACKR1
Autosomique récessifPubMed★ Top pick
ACKR1/Duffy-null genotype testing for clozapine: A guideline developed by the UK Centre of Excellence in Regulatory Science and Innovation in Pharmacogenomics (CERSI-PGx).
ACKR1/Duffy-null associated neutropenia (ADAN) in clozapine-treated patients
9
/10
New recommendationAdverse reaction
British Journal of Clinical Pharmacology 2026· MayRead
CYP2C19
PubMedCYP2C19 genotype-guided antiplatelet therapy to prevent thromboembolic events after stent-assisted coil embolization of unruptured intracranial aneurysms: a retrospective cohort study.
Unruptured intracranial aneurysm treated by stent-assisted coil embolization
7
/10
Dose recommendationAdverse reaction
Journal of Neurointerventional Surgery 2026· MayRead
CYP2C19
PubMedImpact of CYP2C19 and CYP3A4 Inhibitor Use on Clopidogrel Clinical Effectiveness in CYP2C19 Genotyped Patients Undergoing Percutaneous Coronary Intervention.
CYP2C19 phenoconversion under drug inhibitors after percutaneous coronary intervention
8
/10
PhénoconversionAdverse reaction
Clinical Pharmacology and Therapeutics 2026· MayRead
SLCO1B1
PubMedBiomarker-Based Prediction of OATP1B1 Activity in Clinical Routine — Investigating Coproporphyrins as Markers for Drug-Drug-Gene Interactions.
SLCO1B1 phenoconversion in clinical routine: detection by endogenous biomarker
7
/10
PhénoconversionNew interaction
Clinical Pharmacology and Therapeutics 2026· MayRead
Week of 13 May 2026
11 articles
FTO
PubMedFTO rs7195994 Is associated with TNF inhibitor response in lean rheumatoid arthritis patients: A BMI-stratified pharmacogenetic analysis.
Rheumatoid arthritis — TNF inhibitor non-response according to FTO genotype and BMI
8
/10
New interactionRecurrent variant
Pharmacogenomics J 2026· MayRead
CYP2C19
PubMed★ Top pick
Sex Differences in Prognostic Implications of CYP2C19 Genotype After Drug-Eluting Stent Implantation.
Acute coronary syndrome on clopidogrel — CYP2C19 genotype prognostic effect differs by sex
9
/10
Recurrent variantDose recommendation
J Am Heart Assoc 2026· MayRead
CYP2C19
PubMedLimited Visibility and Perception of the Clinical Relevance of Clopidogrel Pharmacogenetics in Cardiology Literature.
Under-implementation of clopidogrel pharmacogenetics in cardiology
7
/10
New recommendationRecurrent variant
Clin Transl Sci 2026· MayRead
CYP2D6
PubMedEffect of Individual and Combined Cytochrome P450 Activity Scores on Symptom Improvement and Side Effects in Youth Treated With Sertraline.
Pediatric mental health conditions treated with sertraline — side effects and symptom improvement by CYP450 genotype
8
/10
PhénoconversionDose recommendation
Clin Transl Sci 2026· MayRead
CYP2C19
PubMedPharmacogenomic Profiling of Voriconazole Enables Predicting Its Toxicity in Pediatric Leukemia and Hematopoietic Stem Cell Transplant Recipients.
Voriconazole toxicity in pediatric leukemia and HSCT — prediction by CYP2C19 genotype
7
/10
Adverse reactionDose recommendation
J Clin Pharmacol 2026· MayRead
DPYD
PubMed★ Top pick
Integrating Somatic and Germline Pharmacogenomics for Therapeutic Decisions in Precision Oncology.
Pharmacogenomics in precision oncology — somatic + germline integration in 10,302 cancer patients (TCGA)
9
/10
Preemptive genotypingCPIC Level A
JCO Precis Oncol 2026· MayRead
Journal
Uncovering Coenzyme Q10-Related Genetic Determinants of Statin-Associated Muscle Symptoms: Evidence from the UK Biobank and the All of Us Research Program
Statin-associated muscle symptoms (SAMS) — genetic determinants related to the coenzyme Q10 pathway
8
/10
Adverse reactionNew interaction
Clin Pharmacol Ther 2026· MayRead
CYP2D6
JournalFrequency of Key Pharmacogenes CYP2C9, CYP2C19, CYP2D6, and SLCO1B1 in the Yogyakarta Population: Implications for Precision Prescribing in Indonesia
PGx allele frequencies (CYP2C9, CYP2C19, CYP2D6, SLCO1B1) in the Yogyakarta population (Indonesia)
8
/10
Recurrent variantPreemptive genotyping
Clin Pharmacol Ther 2026· AprRead
UGT1A1
JournalConcentration dependency of an acyl glucuronide metabolite in eltrombopag-induced hepatotoxicity: Role of UGT1A1 genotype
Eltrombopag-induced hepatotoxicity (thrombopoietin receptor agonist) — role of UGT1A1 genotype
7
/10
Adverse reactionNew interaction
Br J Clin Pharmacol 2026· AprRead
APOE
JournalAPOE genotype and the effect of statins on lipid outcomes: A meta-analysis
Lipid response to statins by APOE genotype — meta-analysis
8
/10
Recurrent variantDose recommendation
Br J Clin Pharmacol 2026· AprRead
HLA-B
PubMedPharmacogenomics in epilepsy care across Asia
Epilepsy in Asia — pharmacogenomics of antiepileptic drugs (HLA-B*15:01, HLA-A*31:01, SCN1A/CYP2C19)
7
/10
CPIC Level AAdverse reaction
Epilepsia 2026· MayRead
Week of 6 May 2026
12 articles
DPYD
PubMed★ Top pick
Importance of and Strategies for Implementing DPYD Testing to Prevent Severe Fluoropyrimidine Chemotherapy Toxicity
Severe fluoropyrimidine toxicity (5-FU, capecitabine, tegafur) — neutropenia, severe mucositis, death
9
/10
CPIC Level ANew recommendation
ASCO Educational Book, 2026· AprRead
CYP2C19
PubMedGenotype-Guided vs Conventional Oral P2Y12 Inhibitors in Acute Coronary Syndrome: A Combined Analysis
Acute coronary syndrome (ACS) — MACE risk under clopidogrel
8
/10
CPIC Level ADose recommendation
JACC: Cardiovascular Interventions, 2026· FebRead
CYP2D6
PubMedEconomic effectiveness of pharmacogenomics-guided prescribing for psychiatric disorders: a systematic review and meta-analysis
Psychiatric disorders — economic efficiency of PGx genotyping
8
/10
CPIC Level APreemptive genotyping
The Pharmacogenomics Journal, 2026· AprRead
NUDT15
PubMedComprehensive overview of the global pharmacogenetic and functional variability in NUDT15
Thiopurine toxicity (mercaptopurine, azathioprine, thioguanine) — severe myelotoxicity
7
/10
CPIC Level AAdverse reaction
Human Genomics, 2026· AprRead
CYP2C19
PubMedInfluence of combined CYP2C19 and CYP2D6 phenotypes on adverse drug reactions in patients with major depressive disorder: a clinical cohort study
Major depressive disorder (MDD) — antidepressant adverse drug reactions
7
/10
CPIC Level APhénoconversion
The Pharmacogenomics Journal, 2026· AprRead
CYP2D6
PubMedA pilot study of pharmacogenomic testing as a tool to enhance depression care in Veterans
Depression in military veterans — implementation of multigene PGx genotyping
7
/10
CPIC Level APreemptive genotyping
The Pharmacogenomics Journal, 2026· AprRead
CYP2C19
PubMedIdentification and functional characterization of 11 novel CYP2C19 variants in the Chinese Han population
CYP2C19 metabolic variability — new alleles in Chinese Han population
7
/10
New interactionRecurrent variant
Pharmacogenomics, 2025· DecRead
CYP2D6
PubMedAnalytical Validation of an Annotation Tool for WGS-Based Pharmacogenomics: Preparing for Clinical Implementation
Clinical implementation of WGS for pharmacogenetics — analytical validation
7
/10
Preemptive genotyping
Clinical and Translational Science, 2026· AprRead
CYP2C19
PubMedChallenges and prospects of CYP2C19 genotype-guided clopidogrel therapy from the perspective of precision medicine
Post-PCI antiplatelet therapy — debate on CYP2C19 genotyping generalization
7
/10
CPIC Level ADose recommendation
Frontiers in Pharmacology, 2026Read
CYP2C9
PubMedDrug-gene interactions and the risk of diabetic microvascular complications: A population-based cohort study
Diabetic microvascular complications — influence of drug-gene interactions on risk
7
/10
Adverse reactionNew interaction
Diabetes, Obesity and Metabolism, 2026· AprRead
DPYD
PubMedDihydropyrimidine dehydrogenase (DPYD) genetic testing and treatment with 5-fluoropyrimidines in cancer patients
Cancer — prevention of 5-fluoropyrimidine toxicity
7
/10
CPIC Level ANew recommendation
Pharmacogenomics, 2026Read
CYP2D6
PubMedPharmacogenetic Variability and Quality of Life in Adolescent Patients with Schizophrenia: The Impact of Metabolizer Status, Symptom Severity, and Adverse Reactions to Antipsychotic Treatment
CYP2D6 PGx variability and antipsychotic tolerability in adolescent schizophrenia patients
7
/10
CPIC Level AAdverse reaction
Journal of Clinical Medicine, 2026· AprRead