Full archive
78 articles across 9 weeks of watch.
Week of 30 June 2026
11 articlesCYP2C19 - Voriconazole after hematopoietic stem cell transplantation — inflammation-driven phenoconversion
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Week of 23 June 2026
8 articlesHealth economics of preemptive pharmacogenetic testing
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Week of 16 June 2026
8 articlesUGT1A1 - Severe irinotecan toxicity in UGT1A1 poor metabolizers
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Week of 10 June 2026
12 articlesL-asparaginase — novel germline genetic risk factor (rs149210846) identified by GWAS for severe drug-induced pancreatitis in pediatric oncohematology
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Week of 3 June 2026
7 articlesCYP2C19 - Gastroesophageal reflux disease — PPI failure, CYP2C19 rapid/ultrarapid metabolizer prevalence
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Week of 27 May 2026
5 articlesCYP2C19 - Depression / Anxiety
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Week of 20 May 2026
4 articlesACKR1 - ACKR1/Duffy-null associated neutropenia (ADAN) in clozapine-treated patients
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Week of 13 May 2026
11 articlesCYP2C19 - Acute coronary syndrome on clopidogrel — CYP2C19 genotype prognostic effect differs by sex
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Week of 6 May 2026
12 articlesDPYD - Severe fluoropyrimidine toxicity (5-FU, capecitabine, tegafur) — neutropenia, severe mucositis, death
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CYP2C19
PubMed★ Top pick
Inflammation-driven variability in drug metabolism: Insights from voriconazole treatment of HSCT recipients
Voriconazole after hematopoietic stem cell transplantation — inflammation-driven phenoconversion
0
PhenoconversionAdverse reaction
Br J Clin Pharmacol 2026· MarRead
L-asparaginase — novel germline genetic risk factor (rs149210846) identified by GWAS for severe drug-induced pancreatitis in pediatric oncohematology
PubMed★ Top pick
⭐ À la une
Novel Genetic Risk Factor Identified for L-Asparaginase-Induced Pancreatitis in Pediatric Patients With Cancer
L-asparaginase — novel germline genetic risk factor (rs149210846) identified by GWAS for severe drug-induced pancreatitis in pediatric oncohematology
0
New interactionAdverse reaction
Pediatr Blood Cancer 2026· MarRead
HLA-B
PubMed★ Top pick
HLA genotype testing for carbamazepine, oxcarbazepine and eslicarbazepine: A guideline developed by the UK Centre of Excellence in Regulatory Science and Innovation in Pharmacogenomics (CERSI-PGx)
Hypersensitivity to carbamazepine, oxcarbazepine and eslicarbazepine — *HLA* genotyping
0
New recommendationAdverse reaction
Br J Clin Pharmacol 2026· AprRead
CYP2C19
PubMed★ Top pick
Paradoxical myocardial infarction risk with dual antiplatelet therapy in East Asian ischaemic stroke: a nationwide real-world cohort study and pharmacogenomic risk prediction model
Secondary ischemic stroke prevention — dual antiplatelet therapy and *CYP2C19* in East Asian populations
0
CardiologyAdverse reactionRecurrent variant
Ther Adv Neurol Disord 2026· JunRead
CYP2C19
medRxiv★ Top pick
Pharmacogenetic phenoconversion modeling of drug-drug-gene interactions on CYP2C19 activity: effects of comedication by genotype on escitalopram concentrations
Escitalopram — modeling of drug-drug-gene interactions on *CYP2C19* activity
0
PhenoconversionNew interaction
medRxiv 2026· JunRead
UGT1A1
PubMed★ Top pick
Real-World Impact of UGT1A1 Genotype-Guided Irinotecan Dosing on Severe Toxicity and Hospitalization: A Multicenter Study.
Severe irinotecan toxicity in UGT1A1 poor metabolizers
0
CPIC Level ADose recommendation
J Natl Compr Canc Netw 2026· JunRead
DPYD
PubMed★ Top pick
DPYD Sequencing Identifies More Clinically Relevant Variants as Compared to Targeted Genotyping
DPYD deficiency — exhaustive sequencing vs targeted genotyping to identify patients at risk of fluoropyrimidine toxicity
0
OncologyCPIC Level ADose recommendation
Clin Chem 2026· JunRead
DPYD
PubMed★ Top pick
Importance of and Strategies for Implementing DPYD Testing to Prevent Severe Fluoropyrimidine Chemotherapy Toxicity in Health Care Systems
DPYD testing implementation before fluoropyrimidines — 2025 FDA recommendations and institutional deployment strategies
0
OncologyCPIC Level ADose recommendation
Am Soc Clin Oncol Educ Book 2026· AprRead
Immunosuppressants
PubMed★ Top pick
Pharmacogenomics of treatment toxicities in pediatric B-Cell ALL: toward safer precision therapy
Pharmacogenomics of treatment toxicities in pediatric B-ALL — TPMT, NUDT15, DPYD, and other CPIC genes
0
ImmunosuppressantsCPIC Level ADose recommendation
Front Pharmacol 2026· JunRead
ACKR1
PubMed★ Top pick
ACKR1/Duffy-null genotype testing for clozapine: A guideline developed by the UK Centre of Excellence in Regulatory Science and Innovation in Pharmacogenomics (CERSI-PGx).
ACKR1/Duffy-null associated neutropenia (ADAN) in clozapine-treated patients
0
New recommendationAdverse reaction
British Journal of Clinical Pharmacology 2026· MayRead
CYP2C19
PubMed★ Top pick
Sex Differences in Prognostic Implications of CYP2C19 Genotype After Drug-Eluting Stent Implantation.
Acute coronary syndrome on clopidogrel — CYP2C19 genotype prognostic effect differs by sex
0
CardiologyRecurrent variantDose recommendation
J Am Heart Assoc 2026· MayRead
DPYD
PubMed★ Top pick
Integrating Somatic and Germline Pharmacogenomics for Therapeutic Decisions in Precision Oncology.
Pharmacogenomics in precision oncology — somatic + germline integration in 10,302 cancer patients (TCGA)
0
OncologyPreemptive genotypingCPIC Level A
JCO Precis Oncol 2026· MayRead
DPYD
PubMed★ Top pick
Importance of and Strategies for Implementing DPYD Testing to Prevent Severe Fluoropyrimidine Chemotherapy Toxicity
Severe fluoropyrimidine toxicity (5-FU, capecitabine, tegafur) — neutropenia, severe mucositis, death
0
OncologyCPIC Level ANew recommendation
ASCO Educational Book, 2026· AprRead
CYP2C19
PubMedCRISPR-Based Assay for Point-of-Care Pharmacogenetic CYP2C19 Genotyping
Point-of-care *CYP2C19* genotyping — CRISPR assay
0
CardiologyPreemptive genotypingNew tool
ACS Sens 2026· JunRead
CYP3A4
PubMedApplication of Virtual Twin PBPK Models in Individuals with Obesity via CYP3A4 Phenotyping Using Endogenous Biomarker Data
Personalized dosing in obese patients — *CYP3A4* phenotyping
0
Dose recommendationPreemptive genotyping
Clin Pharmacol Ther 2026· JunRead
CYP3A4
PubMedOpioid Toxicity Following Concomitant Use of Macrolide Antibiotics with Fentanyl, Hydromorphone, or Oxycodone: A Population-Based Study.
Opioid toxicity from CYP3A4 drug-drug interaction
0
Adverse reactionPhenoconversion
Clin Pharmacol Ther 2026· JunRead
CYP2D6
PubMedHaplo2D6: a web-based tool for automated CYP2D6 haplotype and phenotype inference
CYP2D6 — Haplo2D6 web tool for automated metabolizer haplotype and phenotype inference from genotyping data
0
New toolDose recommendation
Bioinform Adv 2026· MayRead
Diabetes
PubMedPopulation Genomics Insights into Pharmacogenomic Differentiation Between East Asians and Europeans
Pharmacogenomic differentiation between East Asian and European populations — evolutionary disparities and implications for PGx panels
0
DiabetesRecurrent variant
Clin Pharmacol Ther 2026· JunRead
Plasma CYP induction — RT-qPCR on exosomes as non-invasive biomarker of enzymatic induction and drug-drug interactions
PubMedEvaluation of cytochrome P450 (CYP) induction using RT-qPCR in exosomes isolated from plasma samples: Method development and qualification
Plasma CYP induction — RT-qPCR on exosomes as non-invasive biomarker of enzymatic induction and drug-drug interactions
0
PhenoconversionNew tool
Br J Clin Pharmacol 2026· JanRead
CYP2C19
PubMedHigh Prevalence of CYP2C19 Rapid and Ultrarapid Metabolism Among Patients With Gastroesophageal Reflux Disease.
Gastroesophageal reflux disease — PPI failure, CYP2C19 rapid/ultrarapid metabolizer prevalence
0
CPIC Level ADose recommendation
Clin Gastroenterol Hepatol 2026· JunRead
CYP2C19
PubMedImpact of CYP2C19 and CYP3A4 Inhibitor Use on Clopidogrel Clinical Effectiveness in CYP2C19 Genotyped Patients Undergoing Percutaneous Coronary Intervention.
CYP2C19 phenoconversion under drug inhibitors after percutaneous coronary intervention
0
CardiologyPhenoconversionAdverse reaction
Clinical Pharmacology and Therapeutics 2026· MayRead
FTO
PubMedFTO rs7195994 Is associated with TNF inhibitor response in lean rheumatoid arthritis patients: A BMI-stratified pharmacogenetic analysis.
Rheumatoid arthritis — TNF inhibitor non-response according to FTO genotype and BMI
0
New interactionRecurrent variant
Pharmacogenomics J 2026· MayRead
CYP2D6
PubMedEffect of Individual and Combined Cytochrome P450 Activity Scores on Symptom Improvement and Side Effects in Youth Treated With Sertraline.
Pediatric mental health conditions treated with sertraline — side effects and symptom improvement by CYP450 genotype
0
PhenoconversionDose recommendation
Clin Transl Sci 2026· MayRead
Statin-associated muscle symptoms (SAMS) — genetic determinants related to the coenzyme Q10 pathway
PubMedUncovering Coenzyme Q10-Related Genetic Determinants of Statin-Associated Muscle Symptoms: Evidence from the UK Biobank and the All of Us Research Program
Statin-associated muscle symptoms (SAMS) — genetic determinants related to the coenzyme Q10 pathway
0
Adverse reactionNew interaction
Clin Pharmacol Ther 2026· MayRead
CYP2D6
PubMedFrequency of Key Pharmacogenes CYP2C9, CYP2C19, CYP2D6, and SLCO1B1 in the Yogyakarta Population: Implications for Precision Prescribing in Indonesia
PGx allele frequencies (CYP2C9, CYP2C19, CYP2D6, SLCO1B1) in the Yogyakarta population (Indonesia)
0
DiabetesRecurrent variantPreemptive genotyping
Clin Pharmacol Ther 2026· AprRead
APOE
PubMedAPOE genotype and the effect of statins on lipid outcomes: A meta-analysis
Lipid response to statins by APOE genotype — meta-analysis
0
Recurrent variantDose recommendation
Br J Clin Pharmacol 2026· FebRead
CYP2C19
PubMedGenotype-Guided vs Conventional Oral P2Y12 Inhibitors in Acute Coronary Syndrome: A Combined Analysis
Acute coronary syndrome (ACS) — MACE risk under clopidogrel
0
CardiologyCPIC Level ADose recommendation
JACC: Cardiovascular Interventions, 2026· FebRead
CYP2D6
PubMedEconomic effectiveness of pharmacogenomics-guided prescribing for psychiatric disorders: a systematic review and meta-analysis
Psychiatric disorders — economic efficiency of PGx genotyping
0
PsychiatryCPIC Level APreemptive genotyping
The Pharmacogenomics Journal, 2026· AprRead
TPMT
PubMedThe decline of 6-thioguanine nucleotides is not linked to impaired efficacy or safety of thiopurines in pregnant women with inflammatory bowel disease
Thiopurines during pregnancy — inflammatory bowel disease
0
ImmunosuppressantsDose recommendationAdverse reaction
Br J Clin Pharmacol 2026· MarRead
CYP2D6
PubMedPredicting Social Cognitive Outcomes in Adolescent-Onset Schizophrenia: A Hierarchical Analysis of Pharmacogenetic, Clinical, and Environmental Factors
Adolescent-onset schizophrenia — social cognition and *CYP2D6* metabolism
0
PsychiatryPhenoconversionRecurrent variant
J Clin Med 2026· JunRead
CYP2C19
PubMedThe association of ABCB1, CYP2C19 and CYP2C9 combined activity with clopidogrel resistance in patients with recurrent ischemic stroke
Clopidogrel resistance — recurrent ischemic stroke
0
CardiologyRecurrent variantAdverse reaction
Pharmacogenomics J 2026· JunRead
Health economics of preemptive pharmacogenetic testing
PubMed⭐ À la une
Cost-effectiveness of pre-emptive pharmacogenetic testing: An umbrella review
Health economics of preemptive pharmacogenetic testing
0
Preemptive genotypingNew recommendation
PLoS One 2026· JunRead
CYP2D6
PubMedPharmacogenomics for stratified antidepressant treatment in major depressive disorder: evidence, limits and a roadmap for clinical use
Major depressive disorder — pharmacogenetics-guided antidepressant prescribing
0
PsychiatryDose recommendationNew recommendation
Pharmacogenomics 2026· JunRead
CYP3A5
PubMedPreemptive Pharmacogenetics in Renal Transplantation: A Real-World Assessment of Pharmacogenetic Actionability
Renal transplantation — preemptive pharmacogenetics
0
Preemptive genotypingDose recommendation
Ther Drug Monit 2026· JunRead
DPYD
PubMedDPYD polymorphisms in Native populations from the Brazilian Amazon: the absence of the variants in currently recommended clinical genotyping panels
Fluoropyrimidine toxicity — *DPYD* variants in indigenous populations
0
OncologyRecurrent variantAdverse reaction
Pharmacogenet Genomics 2026· JunRead
DPYD
PubMedDPYD and UGT1A1 Genotype-Based Dosing for Fluoropyrimidines and Irinotecan Chemotherapy: Variant-Specific Impact on Treatment Intensity and Toxicity.
Fluoropyrimidine and irinotecan toxicity
0
OncologyCPIC Level ADose recommendation
Int J Cancer 2026· JunRead
CYP2C19
PubMedEvaluation of a pantoprazole and 4-desmethylpantoprazole-sulfate metabolic ratio as a novel CYP2C19 phenotyping method
CYP2C19 functional phenotyping — validation of pantoprazole/4-desmethylpantoprazole-sulfate metabolic ratio as phenotyping probe
0
PhenoconversionNew interaction
Br J Clin Pharmacol 2026· MayRead
CYP3A5
PubMedIntegrating pharmacogenetic and clinical factors to predict the C0/D/W-based tacrolimus phenotype in kidney transplantation
Tacrolimus — pharmacogenetic prediction of pharmacokinetic phenotype (C0/D/W) in kidney transplantation by integrating CYP3A4/CYP3A5 variants and clinical factors
0
Dose recommendationRecurrent variant
Front Pharmacol 2026· MayRead
CYP3A4 drug-drug interaction — voriconazole and posaconazole impact on cyclosporine in pediatric allogeneic HSCT recipients
PubMedImpact of voriconazole/posaconazole on CsA in paediatric allogeneic haematopoietic stem cell transplantation recipients: A real-world study
CYP3A4 drug-drug interaction — voriconazole and posaconazole impact on cyclosporine in pediatric allogeneic HSCT recipients
0
PhenoconversionDose recommendation
Br J Clin Pharmacol 2026· MayRead
DPYD
PubMedConsiderations for the clinical implementation of DPYD and UGT1A1-guided chemotherapy
DPYD and UGT1A1 — clinical implementation of pharmacogenomic testing guiding fluoropyrimidine and irinotecan chemotherapy
0
OncologyCPIC Level ADose recommendation
Pharmacogenomics 2026· JunRead
DPYD
PubMedClinical response to capecitabine in a DPYD*2A homozygous patient: Case report and therapeutic guidance.
Complete DPD deficiency (DPYD*2A homozygous) — ultra-low-dose capecitabine
0
OncologyCPIC Level AAdverse reaction
Br J Clin Pharmacol 2026· MayRead
CYP2C19
PubMedGenotype influences antidepressant discontinuation in a pre-emptive pharmacogenetic testing population.
Depression / Anxiety
0
Preemptive genotypingAdverse reaction
Pharmacogenomics J 2026· MayRead
Pharmacogenetics in intensive care
PubMedImpact of population-specific pharmacogenomic variants on drug dosing in ICU patients.
Pharmacogenetics in intensive care
0
Preemptive genotypingDose recommendation
Pharmacogenomics J 2026· MayRead
CYP2D6
PubMedIdentification and drug metabolic activity evaluation of 12 CYP2D6 allelic variants newly detected in the Chinese population.
Pharmacogenetics — drug metabolism
0
Recurrent variantNew interaction
Gene 2026· MayRead
DPYD
PubMedCost-effectiveness of DPYD genotyping prior to fluoropyrimidine-based treatment for colorectal cancer in Wales.
Colorectal cancer — fluoropyrimidine toxicity
0
OncologyCPIC Level ADose recommendation
Br J Clin Pharmacol 2026· MayRead
CYP2C19
PubMedCYP2C19 genotype-guided antiplatelet therapy to prevent thromboembolic events after stent-assisted coil embolization of unruptured intracranial aneurysms: a retrospective cohort study.
Unruptured intracranial aneurysm treated by stent-assisted coil embolization
0
CardiologyDose recommendationAdverse reaction
Journal of Neurointerventional Surgery 2026· MayRead
SLCO1B1
PubMedBiomarker-Based Prediction of OATP1B1 Activity in Clinical Routine — Investigating Coproporphyrins as Markers for Drug-Drug-Gene Interactions.
SLCO1B1 phenoconversion in clinical routine: detection by endogenous biomarker
0
DiabetesPhenoconversionNew interaction
Clinical Pharmacology and Therapeutics 2026· MayRead
CYP2C19
PubMedLimited Visibility and Perception of the Clinical Relevance of Clopidogrel Pharmacogenetics in Cardiology Literature.
Under-implementation of clopidogrel pharmacogenetics in cardiology
0
CardiologyNew recommendationRecurrent variant
Clin Transl Sci 2026· MayRead
CYP2C19
PubMedPharmacogenomic Profiling of Voriconazole Enables Predicting Its Toxicity in Pediatric Leukemia and Hematopoietic Stem Cell Transplant Recipients.
Voriconazole toxicity in pediatric leukemia and HSCT — prediction by CYP2C19 genotype
0
Adverse reactionDose recommendation
J Clin Pharmacol 2026· MayRead
UGT1A1
PubMedConcentration dependency of an acyl glucuronide metabolite in eltrombopag-induced hepatotoxicity: Role of UGT1A1 genotype
Eltrombopag-induced hepatotoxicity (thrombopoietin receptor agonist) — role of UGT1A1 genotype
0
Adverse reactionNew interaction
Br J Clin Pharmacol 2026· AprRead
HLA-B
PubMedPharmacogenomics in epilepsy care across Asia
Epilepsy in Asia — pharmacogenomics of antiepileptic drugs (HLA-B*15:01, HLA-A*31:01, SCN1A/CYP2C19)
0
CPIC Level AAdverse reaction
Fam Cancer 2026· MayRead
NUDT15
PubMedComprehensive overview of the global pharmacogenetic and functional variability in NUDT15
Thiopurine toxicity (mercaptopurine, azathioprine, thioguanine) — severe myelotoxicity
0
ImmunosuppressantsCPIC Level AAdverse reaction
Human Genomics, 2026· AprRead
CYP2C19
PubMedInfluence of combined CYP2C19 and CYP2D6 phenotypes on adverse drug reactions in patients with major depressive disorder: a clinical cohort study
Major depressive disorder (MDD) — antidepressant adverse drug reactions
0
PsychiatryCPIC Level APhenoconversion
The Pharmacogenomics Journal, 2026· AprRead
CYP2D6
PubMedA pilot study of pharmacogenomic testing as a tool to enhance depression care in Veterans
Depression in military veterans — implementation of multigene PGx genotyping
0
PsychiatryCPIC Level APreemptive genotyping
The Pharmacogenomics Journal, 2026· AprRead
CYP2C19
PubMedIdentification and functional characterization of 11 novel CYP2C19 variants in the Chinese Han population
CYP2C19 metabolic variability — new alleles in Chinese Han population
0
New interactionRecurrent variant
Pharmacogenomics, 2025· DecRead
CYP2D6
PubMedAnalytical Validation of an Annotation Tool for WGS-Based Pharmacogenomics: Preparing for Clinical Implementation
Clinical implementation of WGS for pharmacogenetics — analytical validation
0
Preemptive genotyping
Clinical and Translational Science, 2026· AprRead
CYP2C19
PubMedChallenges and prospects of CYP2C19 genotype-guided clopidogrel therapy from the perspective of precision medicine
Post-PCI antiplatelet therapy — debate on CYP2C19 genotyping generalization
0
CardiologyCPIC Level ADose recommendation
Frontiers in Pharmacology, 2026Read
CYP2C9
PubMedDrug-gene interactions and the risk of diabetic microvascular complications: A population-based cohort study
Diabetic microvascular complications — influence of drug-gene interactions on risk
0
DiabetesAdverse reactionNew interaction
Diabetes, Obesity and Metabolism, 2026· AprRead
DPYD
PubMedDihydropyrimidine dehydrogenase (DPYD) genetic testing and treatment with 5-fluoropyrimidines in cancer patients
Cancer — prevention of 5-fluoropyrimidine toxicity
0
OncologyCPIC Level ANew recommendation
Pharmacogenomics, 2026Read
CYP2D6
PubMedPharmacogenetic Variability and Quality of Life in Adolescent Patients with Schizophrenia: The Impact of Metabolizer Status, Symptom Severity, and Adverse Reactions to Antipsychotic Treatment
CYP2D6 PGx variability and antipsychotic tolerability in adolescent schizophrenia patients
0
PsychiatryCPIC Level AAdverse reaction
Journal of Clinical Medicine, 2026· AprRead
Adverse drug reactions — burden of metabolic pathway inhibition
PubMedThe quantitative impact of metabolism-inhibiting drugs on the occurrence of adverse drug reactions — A backward selection approach
Adverse drug reactions — burden of metabolic pathway inhibition
0
Adverse reactionPhenoconversion
Br J Clin Pharmacol 2026· FebRead
CYP2C19
PubMedA primary care pharmacogenetic precision medicine pilot based on specific Māori tribal ethical frameworks and principles
Primary care pharmacogenetics — Māori tribal ethical framework
0
Preemptive genotypingRecurrent variant
J Community Genet 2026· JunRead
HLA-B
PubMedSystematic review on genetic polymorphisms associated with idiosyncratic drug-induced liver injury (iDILI): iDILInet as an interactive visualization tool
Idiosyncratic drug-induced liver injury (iDILI) — genetic susceptibility
0
Adverse reactionNew tool
Acta Pharm Sin B 2026· MarRead
CYP2D6
PubMedDoes Next Generation Sequencing (NGS)-Based CYP2D6 Sequencing Improve Genotype-Phenotype Concordance in Tamoxifen-Treated Patients?
Breast cancer — tamoxifen and *CYP2D6* phenotyping by NGS
0
Dose recommendationRecurrent variant
Clin Pharmacol Ther 2026· JunRead
Pharmacogenetics — benchmark of star-allele calling tools
PubMedBenchmark of Open-Access Star-Allele Callers to Accurately Assess Haplotypes and Phenotypes in Pharmacogenetic Studies
Pharmacogenetics — benchmark of star-allele calling tools
0
BenchmarkNew tool
Clin Pharmacol Ther 2026· JunRead
CYP2C19
PubMedCombinations of single gene predictors with AI-driven polygenic precision therapies in cardiovascular diseases.
Cardiovascular diseases / pharmacogenomics
0
DiabetesCPIC Level APreemptive genotyping
Pharmacogenomics 2026· JunRead
VKORC1
PubMedDerivation and Validation of a Genotype-Guided Warfarin Dosing Model in a Mixed Arab Population.
Warfarin anticoagulation / interindividual variability
0
DiabetesCPIC Level ADose recommendation
Clin Appl Thromb Hemost 2026· JanRead
CYP3A4
PubMedHow Drug-Drug Interaction Studies Inform Drug Labeling: A Survey of US FDA-Approved New Molecular Entities from 1998 to 2022.
Drug-drug interactions / FDA labeling
0
New interaction
Clin Pharmacol Ther 2026· JunRead
CYP3A5
PubMedPopulation pharmacokinetics of tacrolimus and CYP3A5-driven variability: implications for model-informed dose individualization in pediatric renal transplant recipients.
Tacrolimus PK variability in pediatric renal transplantation
0
Dose recommendationRecurrent variant
BMC Pharmacol Toxicol 2026· JunRead
HLA-B
PubMedPharmacogenomics of antibacterial and antiviral therapies: Clinical actionability, evidence gaps, and future directions.
Pharmacogenomics of anti-infective therapies
0
CPIC Level APreemptive genotyping
Pharmacol Rev 2026· AprRead
NUDT15
Journal6-Mercaptopurine metabolic profiles and clinical outcomes in TPMT and NUDT15 phenotypes during maintenance therapy for Thai paediatric acute lymphoblastic leukaemia
6-mercaptopurine — metabolic profiles and clinical toxicity by combined TPMT/NUDT15 phenotype in Thai pediatric ALL
0
ImmunosuppressantsCPIC Level ADose recommendation
Br J Clin Pharmacol 2026· JunRead
CYP2C19
PubMedOptimizing P2Y12 Inhibitor Therapy in Post-PCI Patients Through Genotype-Guided Strategies: A Systematic Review and Meta-Analysis.
Post-PCI — CYP2C19 genotype-guided P2Y12 inhibitor therapy optimization
0
CardiologyCPIC Level APreemptive genotyping
Cardiovasc Drugs Ther 2026· JunRead
TPMT
PubMedTherapeutic Drug Monitoring and Pharmacogenomics of Thiopurines in Inflammatory Bowel Disease: International Guidelines Revisited.
IBD — thiopurine monitoring, TPMT/NUDT15 PGx and therapeutic drug monitoring
0
ImmunosuppressantsCPIC Level ANew recommendation
Ther Drug Monit 2026· JunRead
CYP2D6
PubMedAripiprazole and CYP2D6: A retrospective cohort study evaluating the impact of phenotype on metabolic abnormalities.
Aripiprazole — metabolic abnormalities by CYP2D6 phenotype and phenoconversion
0
PsychiatryPhenoconversionAdverse reaction
Am J Health Syst Pharm 2026· MayRead
NAT2
PubMedAcetylation Variability in Elderly Tunisians: Implications for Isoniazid Dose Individualization.
Tuberculosis — NAT2 acetylation variability, isoniazid dose individualization in elderly patients
0
Dose recommendationAdverse reaction
J Clin Pharmacol 2026· JunRead
CYP2C19
PubMedVoriconazole therapy and CYP2C19 phenotype: identifying patients who may need alternative antifungal therapy.
Invasive fungal infections — voriconazole
0
Adverse reactionDose recommendation
J Antimicrob Chemother 2026· MayRead
CYP2B6
PubMedClinical Relevance of the 516 G>T Polymorphism in CYP2B6 and Its Effects on Efavirenz Concentrations in Patients with HIV and Tuberculosis: A Meta-analysis
Efavirenz in HIV/tuberculosis patients — *CYP2B6* 516 G>T polymorphism
0
Recurrent variantAdverse reaction
Eur J Drug Metab Pharmacokinet 2026· JunRead
CYP1A2
PubMedEffects of Repeated Smoking and Quitting Cigarettes on Plasma Concentrations of Clozapine and Its N-Desmethyl and N-Oxide Metabolites in a Japanese Patient With Schizophrenia.
Clozapine — CYP1A2 phenoconversion by smoking and smoking cessation
0
PsychiatryPhenoconversionAdverse reaction
Neuropsychopharmacol Rep 2026· JunRead