Pharmacogenomics

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Pharmacogenomics

Week of 23 June 2026

8 articles

Geno'X Veille — genox-veille.fr

Key takeaways this week

►Preemptive PGx cost-effectiveness — 71% of 211 pharmacoeconomic evaluations conclude positively: the most robust synthesis to date.
►CYP3A4 and bariatric obesity — PBPK virtual twin via endogenous 4β-OHC biomarker, 85–87% of predictions within twofold of observed.
►DPYD in Amazonian indigenous populations — current CPIC panels miss the mark: documented equity gap for fluoropyrimidines.

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Application of Virtual Twin PBPK Models in Individuals with Obesity via CYP3A4 Phenotyping Using Endogenous Biomarker Data

Personalized dosing in obese patients — *CYP3A4* phenotyping

Dose recommendationPreemptive genotyping

Clin Pharmacol Ther 2026· JunRead

The association of ABCB1, CYP2C19 and CYP2C9 combined activity with clopidogrel resistance in patients with recurrent ischemic stroke

Clopidogrel resistance — recurrent ischemic stroke

CardiologyRecurrent variantAdverse reaction

Pharmacogenomics J 2026· JunRead

Health economics of preemptive pharmacogenetic testing

Cost-effectiveness of pre-emptive pharmacogenetic testing: An umbrella review

Health economics of preemptive pharmacogenetic testing

Preemptive genotypingNew recommendation

PLoS One 2026· JunRead

Pharmacogenomics for stratified antidepressant treatment in major depressive disorder: evidence, limits and a roadmap for clinical use

Major depressive disorder — pharmacogenetics-guided antidepressant prescribing

PsychiatryDose recommendationNew recommendation

Pharmacogenomics 2026· JunRead

Preemptive Pharmacogenetics in Renal Transplantation: A Real-World Assessment of Pharmacogenetic Actionability

Renal transplantation — preemptive pharmacogenetics

Preemptive genotypingDose recommendation

Ther Drug Monit 2026· JunRead

DPYD polymorphisms in Native populations from the Brazilian Amazon: the absence of the variants in currently recommended clinical genotyping panels

Fluoropyrimidine toxicity — *DPYD* variants in indigenous populations

OncologyRecurrent variantAdverse reaction

Pharmacogenet Genomics 2026· JunRead

Does Next Generation Sequencing (NGS)-Based CYP2D6 Sequencing Improve Genotype-Phenotype Concordance in Tamoxifen-Treated Patients?

Breast cancer — tamoxifen and *CYP2D6* phenotyping by NGS

Dose recommendationRecurrent variant

Clin Pharmacol Ther 2026· JunRead

Pharmacogenetics — benchmark of star-allele calling tools

Benchmark of Open-Access Star-Allele Callers to Accurately Assess Haplotypes and Phenotypes in Pharmacogenetic Studies

Pharmacogenetics — benchmark of star-allele calling tools

BenchmarkNew tool

Clin Pharmacol Ther 2026· JunRead

References and sources

CYP3A4 — Personalized dosing in obese patients — *CYP3A4* phenotyping. Clin Pharmacol Ther 2026. PMID 42317011. Score 8/10. https://pubmed.ncbi.nlm.nih.gov/42317011/
CYP2C19 — Clopidogrel resistance — recurrent ischemic stroke. Pharmacogenomics J 2026. PMID 42303966. Score 7/10. https://pubmed.ncbi.nlm.nih.gov/42303966/
Health economics of preemptive pharmacogenetic testing. PLoS One 2026. PMID 42302010. Score 7/10. https://pubmed.ncbi.nlm.nih.gov/42302010/
CYP2D6 — Major depressive disorder — pharmacogenetics-guided antidepressant prescribing. Pharmacogenomics 2026. PMID 42299141. Score 7/10. https://pubmed.ncbi.nlm.nih.gov/42299141/
CYP3A5 — Renal transplantation — preemptive pharmacogenetics. Ther Drug Monit 2026. PMID 42307594. Score 7/10. https://pubmed.ncbi.nlm.nih.gov/42307594/
DPYD — Fluoropyrimidine toxicity — *DPYD* variants in indigenous populations. Pharmacogenet Genomics 2026. PMID 42329750. Score 7/10. https://pubmed.ncbi.nlm.nih.gov/42329750/
CYP2D6 — Breast cancer — tamoxifen and *CYP2D6* phenotyping by NGS. Clin Pharmacol Ther 2026. PMID 42312965. Score 6/10. https://pubmed.ncbi.nlm.nih.gov/42312965/
Pharmacogenetics — benchmark of star-allele calling tools. Clin Pharmacol Ther 2026. PMID 42312650. Score 6/10. https://pubmed.ncbi.nlm.nih.gov/42312650/