Pharmacogenomics

GénGermline OncoOnco PGxPGx BioBioinfo

Pharmacogenomics

Week of 7 July 2026

5 articles

Geno'X Veille — genox-veille.fr

Key takeaways this week

►CYP2C8 — novel functional allele (*19) altering splicing, +45% repaglinide exposure.
►UGT1A1 — new UK guideline (CERSI-PGx): −30% irinotecan at Cycle 1 in poor metabolisers.
►CYP2D6 — long-read resolves structural complexity, key for tamoxifen dosing.

Category:

Filters··Min. score

5 articles of 5

Sort

Identification of a Functional CYP2C8 Variant Allele that Alters Splicing, Reduces Protein Expression, and Increases Drug Exposure.

CYP2C8 pharmacogenetics (repaglinide, gemfibrozil)

New interaction

Clin Pharmacol Ther 2026· JulRead

Resolving CYP2D6 Structural Complexity with Long-Read Sequencing: Implications for Tamoxifen Precision Dosing in Thai Breast Cancer Patients.

CYP2D6 pharmacogenetics (tamoxifen)

Dose recommendation

Clin Pharmacol Ther 2026· JulRead

UGT1A1 genotype testing for irinotecan: A guideline developed by the UK Centre of Excellence in Regulatory Science and Innovation in Pharmacogenomics (CERSI-PGx).

Irinotecan pharmacogenetics (UGT1A1)

New recommendationDose recommendation

Br J Clin Pharmacol 2026· JulRead

Anti-seizure medication-induced DRESS (paediatrics)

Anti-seizure medications and DRESS in paediatric patients: A FAERS disproportionality and time-to-onset analysis.

Anti-seizure medication-induced DRESS (paediatrics)

Adverse reaction

Br J Clin Pharmacol 2026· JulRead

Machine learning-based model for prediction of carbamazepine- and allopurinol-induced severe cutaneous adverse reactions in Vietnamese.

Carbamazepine- and allopurinol-induced severe cutaneous adverse reactions (SCARs)

CardiologyAdverse reaction

World Allergy Organ J 2026· JunRead

References and sources

CYP2C8 — CYP2C8 pharmacogenetics (repaglinide, gemfibrozil). Clin Pharmacol Ther 2026. PMID 42387303. Score 10/10. https://pubmed.ncbi.nlm.nih.gov/42387303/
CYP2D6 — CYP2D6 pharmacogenetics (tamoxifen). Clin Pharmacol Ther 2026. PMID 42387636. Score 9/10. https://pubmed.ncbi.nlm.nih.gov/42387636/
UGT1A1 — Irinotecan pharmacogenetics (UGT1A1). Br J Clin Pharmacol 2026. PMID 42389808. Score 8/10. https://pubmed.ncbi.nlm.nih.gov/42389808/
Anti-seizure medication-induced DRESS (paediatrics). Br J Clin Pharmacol 2026. PMID 42397303. Score 7/10. https://pubmed.ncbi.nlm.nih.gov/42397303/
HLA-B — Carbamazepine- and allopurinol-induced severe cutaneous adverse reactions (SCARs). World Allergy Organ J 2026. PMID 42292762. Score 6/10. https://pubmed.ncbi.nlm.nih.gov/42292762/