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Pharmacogenomics
Week of 28 July 2026
11 articles
Geno'X Veille — genox-veille.fr
Key takeaways this week
- ►CYP2C19 — 81% of patients on antiplatelet therapy after stroke also receive another CYP2C19 substrate: genotype reaches far beyond antiplatelet selection.
- ►HLA-B 15:21 — 5.9% residual cutaneous risk on carbamazepine after a negative HLA-B 15:02 screen.
- ►NUDT15/IL6 — IL6 proposed as an independent contributor to thiopurine-induced leukopenia in Korean patients.
- ►PGx in paediatric critical care — 37% of children receive at least one drug with established pharmacogenomic guidelines, with no genotyping at all.
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CYP2C19
PubMedExposure to CYP2C19-metabolized drugs following acute stroke: A longitudinal cohort study to inform implementation of CYP2C19 genotype testing.
Ischaemic stroke — exposure to CYP2C19 substrates
0
CardiologyPreemptive genotyping
Br J Clin Pharmacol 2026· JulRead
Psychiatry
medRxivGenomic and transcriptomic insights into antipsychotic-induced changes in total cholesterol and body mass index in a multi-ancestry cohort of the US veterans
Antipsychotic-induced metabolic effects (total cholesterol, BMI)
0
PsychiatryAdverse reaction
medRxiv 2026· JulRead
Diabetes
PubMedDisentangling Sex Differences in Sulfonylurea Drug Response With Genome-Wide Association Studies in Individuals With Type 2 Diabetes.
Sulfonylurea response in type 2 diabetes
0
DiabetesNew interaction
Clin Pharmacol Ther 2026· JulRead
HLA-B
PubMedHLA-B 15:21 carrier status is a susceptibility factor of carbamazepine-induced nonimmediate cutaneous adverse reactions in HLA-B 15:02-negative patients: A retrospective cohort study.
Nonimmediate cutaneous adverse reactions to carbamazepine
0
Adverse reactionPreemptive genotyping
Br J Clin Pharmacol 2026· JulRead
Diabetes
medRxivCritically Ill Children Frequently Receive Medications with Established but Unused Pharmacogenomic Guidelines: Actionable Findings from an Integrated Electronic Medical Record and Exome Sequencing Study
Paediatric intensive care — medications with established pharmacogenomic guidelines
0
DiabetesPreemptive genotyping
medRxiv 2026· JulRead
NUDT15
PubMedPharmacogenetic Risk Factors for Thiopurine-Induced Leukopenia in Patients with Inflammatory Bowel Disease.
Thiopurine-induced leukopenia in inflammatory bowel disease
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ImmunosuppressantsAdverse reactionPreemptive genotyping
Yonsei Med J 2026· JulRead
OPRM1
PubMedRole of Genetic Polymorphisms on Opioid Safety and Efficacy in Cancer Pain: A Systematic Review and Meta-Analysis.
Cancer pain — opioid efficacy and safety
0
Adverse reaction
Eur J Pharmacol 2026· JulRead
Chemotherapy-induced peripheral neuropathy
PubMedWhy pharmacogenomic biomarkers for chemotherapy-induced peripheral neuropathy fail: a systematic review of genetic associations, replication, and clinical translation.
Chemotherapy-induced peripheral neuropathy
0
Adverse reaction
Front Pharmacol 2026· JulRead
CYP3A5
PubMedToward individualized precision dosing of perampanel: Integrating therapeutic drug monitoring, drug-drug interactions, and pharmacogenetics.
Drug-resistant epilepsy — individualised perampanel dosing
0
Dose recommendation
Eur J Pharm Sci 2026· JulRead
CYP2C19
PubMedIntegrating Clinical Evidence with PBPK Modeling to Assess PPI-Clopidogrel-CYP2C19 Interactions in Chinese ACS Patients.
Acute coronary syndrome — PPI-clopidogrel interaction
0
CardiologyPhenoconversion
Pharm Res 2026· JulRead
CYP2D6
PubMedMetoprolol Population Pharmacokinetics in Older Chinese Patients With CKM Syndrome: Joint Effects of rs1065852 and CKM2S2-BAG Score on Clearance.
Cardiovascular-kidney-metabolic syndrome in older adults — metoprolol exposure
0
Dose recommendation
Clin Transl Sci 2026· JulRead
References and sources
- HLA-B — Nonimmediate cutaneous adverse reactions to carbamazepine. Br J Clin Pharmacol 2026. PMID 42504015. Score 6/10. https://pubmed.ncbi.nlm.nih.gov/42504015/
- Paediatric intensive care — medications with established pharmacogenomic guidelines. medRxiv 2026. doi:10.64898/2026.07.16.26358240. Score 6/10. https://www.medrxiv.org/content/10.64898/2026.07.16.26358240v1
- CYP2C19 — Ischaemic stroke — exposure to CYP2C19 substrates. Br J Clin Pharmacol 2026. PMID 42500815. Score 7/10. https://pubmed.ncbi.nlm.nih.gov/42500815/
- NUDT15 — Thiopurine-induced leukopenia in inflammatory bowel disease. Yonsei Med J 2026. PMID 42494268. Score 6/10. https://pubmed.ncbi.nlm.nih.gov/42494268/
- Antipsychotic-induced metabolic effects (total cholesterol, BMI). medRxiv 2026. doi:10.64898/2026.07.20.26358275. Score 7/10. https://www.medrxiv.org/content/10.64898/2026.07.20.26358275v1
- Sulfonylurea response in type 2 diabetes. Clin Pharmacol Ther 2026. PMID 42504935. Score 7/10. https://pubmed.ncbi.nlm.nih.gov/42504935/
- OPRM1 — Cancer pain — opioid efficacy and safety. Eur J Pharmacol 2026. PMID 42492880. Score 6/10. https://pubmed.ncbi.nlm.nih.gov/42492880/
- Chemotherapy-induced peripheral neuropathy. Front Pharmacol 2026. PMID 42494534. Score 6/10. https://pubmed.ncbi.nlm.nih.gov/42494534/
- CYP3A5 — Drug-resistant epilepsy — individualised perampanel dosing. Eur J Pharm Sci 2026. PMID 42486344. Score 5/10. https://pubmed.ncbi.nlm.nih.gov/42486344/
- CYP2C19 — Acute coronary syndrome — PPI-clopidogrel interaction. Pharm Res 2026. PMID 42481856. Score 5/10. https://pubmed.ncbi.nlm.nih.gov/42481856/
- CYP2D6 — Cardiovascular-kidney-metabolic syndrome in older adults — metoprolol exposure. Clin Transl Sci 2026. PMID 42496093. Score 5/10. https://ascpt.onlinelibrary.wiley.com/doi/10.1111/cts.70677?af=R
