Pharmacogenomics

GénGermline OncoOnco PGxPGx BioBioinfo

Subscribe Support

Pharmacogenomics

Week of 11 August 2026

10 articles

Geno'X Veille — genox-veille.fr

Key takeaways this week

►TPMT / NUDT15 — the CPIC curation panel designates decreased function alleles in both genes for the first time and reclassifies several previously uncertain-function alleles.
►Depression — the randomised trial of 201 patients shows no benefit of combinatorial pharmacogenomic testing on well-being at 12 months (difference -0.6; 95% CI -1.8 to 0.5), whereas a retrospective study of 6,224 patients linked such testing to better adherence (proportion of days covered 0.65 versus 0.61).
►NAT2 — long-read sequencing exceeds 99% diplotype accuracy across 1,828 samples and reveals 11 new star alleles, yet a 4-SNP panel already predicts phenotype correctly in more than 95% of subjects, except in non-white individuals.
►UGT1A1 — the only reproducible pharmacogenomic signal for dolutegravir, with an effect size too small to justify routine genotyping.
►CYP2C19 — among 114,627 participants on escitalopram or citalopram, 29.7% of poor metabolizers discontinue treatment for side effects versus 21.6% of ultrarapid metabolizers.

Category:

Filters··Min. score

10 articles of 10

Sort

Clinical Functional Assignment of TPMT and NUDT15 Alleles by the Clinical Pharmacogenetics Implementation Consortium Pharmacogene Curation Expert Panel.

Thiopurine toxicity and dose adjustment

ImmunosuppressantsCPIC Level ANew recommendation

Clin Pharmacol Ther 2026· AugRead

Characterization of NAT2 Using Long-Read Sequencing: Allele, Diplotype, and Phenotype Call Accuracy Compared to Other Testing Strategies.

Acetylator status and NAT2 pharmacogenetic typing

Recurrent variant

Clin Pharmacol Ther 2026· AugRead

Large-scale analysis demonstrates the influence of CYP2C19 genotype on specific SSRI side effects.

Selective serotonin reuptake inhibitor side effects

PsychiatryCPIC Level AAdverse reaction

Pharmacogenomics J 2026· AugRead

Comparative Effectiveness of Pharmacogenomics for Treatment of Depression.

Major depressive disorder

J Clin Psychopharmacol 2026· AugRead

Pharmacogenomics of dolutegravir: A scoping review of evidence, gaps and clinical implications.

HIV infection treated with dolutegravir

Br J Clin Pharmacol 2026· JulRead

Pre-emptive CYP2C19 genotyping and voriconazole exposure in pediatric hematology patients at risk of aspergillosis: an exploratory randomized pilot study with a cost-consequence analysis.

Voriconazole exposure in paediatric haematology

CPIC Level APreemptive genotyping

Front Pharmacol 2026· AugRead

Medication adherence following pharmacogenomic testing in patients with major depressive disorder.

Major depressive disorder

Psychiatry Res 2026· AugRead

A single-arm phase II trial of UGT1A1 genotype-guided high-dose irinotecan rechallenge in refractory metastatic colorectal cancer.

Refractory metastatic colorectal cancer

Dose recommendation

Front Oncol 2026· AugRead

Association of a CCB-Related Pharmacogenomics-Guided Strategy with Blood Pressure Outcomes and Short-Term Safety in Chinese Patients with Hypertension: A Secondary Exploratory Analysis of Two Randomized Cohorts.

Hypertension treated with calcium channel blockers

Preemptive genotyping

Drug Healthc Patient Saf 2026· AugRead

Pharmacogenomic biomarkers in oncology: evidence, clinical utility, and barriers to implementation.

Pharmacogenomic biomarkers in oncology

OncologyCPIC Level ADose recommendation

J Chemother 2026· AugRead

References and sources

TPMT — Thiopurine toxicity and dose adjustment. Clin Pharmacol Ther 2026. PMID 42560154. Score 8/10. https://pubmed.ncbi.nlm.nih.gov/42560154/
NAT2 — Acetylator status and NAT2 pharmacogenetic typing. Clin Pharmacol Ther 2026. PMID 42572153. Score 7/10. https://pubmed.ncbi.nlm.nih.gov/42572153/
CYP2C19 — Selective serotonin reuptake inhibitor side effects. Pharmacogenomics J 2026. PMID 42552300. Score 7/10. https://pubmed.ncbi.nlm.nih.gov/42552300/
CYP2C19 — Voriconazole exposure in paediatric haematology. Front Pharmacol 2026. PMID 42553256. Score 5/10. https://pubmed.ncbi.nlm.nih.gov/42553256/
UGT1A1 — Refractory metastatic colorectal cancer. Front Oncol 2026. PMID 42558275. Score 4/10. https://pubmed.ncbi.nlm.nih.gov/42558275/
CYP3A5 — Hypertension treated with calcium channel blockers. Drug Healthc Patient Saf 2026. PMID 42553612. Score 4/10. https://pubmed.ncbi.nlm.nih.gov/42553612/
Pharmacogenomic biomarkers in oncology. J Chemother 2026. PMID 42560047. Score 3/10. https://pubmed.ncbi.nlm.nih.gov/42560047/
Major depressive disorder. Psychiatry Res 2026. PMID 42567079. Score 5/10. https://pubmed.ncbi.nlm.nih.gov/42567079/
Major depressive disorder. J Clin Psychopharmacol 2026. PMID 42572938. Score 7/10. https://pubmed.ncbi.nlm.nih.gov/42572938/
UGT1A1 — HIV infection treated with dolutegravir. Br J Clin Pharmacol 2026. PMID 42521219. Score 7/10. https://bpspubs.onlinelibrary.wiley.com/doi/10.1002/bcp.70721?af=R