Pharmacogenomics

Week of 27 October 2026

9 articles

Geno'X Veille — genox-veille.fr

Key takeaways this week

►DPYD — systematic review of 23 Asian and African studies: in Zimbabwe, no carrier of the four guideline variants among 150 genotyped patients, yet 36% of the 50 treated had a severe adverse event on fluoropyrimidine.
►NUDT15 / TPMT — in 124 Thai patients with inflammatory bowel disease, 16.9% carried a NUDT15 variant versus 4.8% for TPMT; only NUDT15 was associated with azathioprine-induced myelosuppression (19% vs. 7.8%).
►Polygenic score — in simulations, trial eligibility criteria alone create an apparently greater lipid-lowering benefit in individuals with high coronary PRS (HR 0.77 vs. 0.95), an effect with little or no support in the Helix and UK Biobank cohorts.
►HLA-F — PROCURE: in 290 patients on trastuzumab deruxtecan, the strongest interstitial lung disease signal lies near HLA-F (OR 6.8), with no definitive pharmacogenomic predictor.
►CYP2D6 — in lupus, genotype determines exposure to DHCQ, the active metabolite of hydroxychloroquine, but only DHCQ, not genotype, is associated with low disease activity (102 patients).

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Association Between DPYD Gene Variants and Severe Fluoropyrimidine-Related Toxicity in Asian and African Populations: A Systematic Review.

Severe fluoropyrimidine toxicity in solid tumors

OncologyAdverse reactionRecurrent variant

Pharmgenomics Pers Med 2026· OctRead

HLA-F, SLCO1B1, CYP3A4

Germline pharmacogenetic variants associated with trastuzumab deruxtecan-induced interstitial lung disease in advanced breast cancer: PROCURE project.

Trastuzumab deruxtecan-induced interstitial lung disease in advanced breast cancer

Adverse reaction

ESMO Open 2026· OctRead

Prevalence and impact of Thiopurine S-methyltransferase (TPMT) and Nudix hydrolase 15 (NUDT15) polymorphisms on the occurrence of myelosuppression in Thai patients with inflammatory bowel disease receiving thiopurine therapy.

Inflammatory bowel disease treated with azathioprine

ImmunosuppressantsAdverse reactionPreemptive genotyping

Crohns Colitis 360 2026· OctRead

Polygenic prediction of treatment response for precision medicine is vulnerable to collider bias

Lipid-lowering cardiovascular prevention

medRxiv 2026· OctRead

Desethylhydroxychloroquine and CYP2D6 polymorphisms are associated with low disease activity in patients with systemic lupus erythematosus.

Systemic lupus erythematosus treated with hydroxychloroquine

Br J Clin Pharmacol 2026· OctRead

The prevalence and impacts of NUDT15 variants in pediatric-onset inflammatory bowel disease patients in Taiwan.

Pediatric-onset inflammatory bowel disease treated with thiopurines

ImmunosuppressantsAdverse reactionPreemptive genotyping

Pediatr Neonatol 2026· OctRead

TPMT, NUDT15, DPYD, UGT1A1

Pharmacogenetics in pediatric oncology: Current evidence and challenges for clinical implementation.

Childhood cancers treated with antineoplastic agents

OncologyAdverse reactionPhenoconversion

Farm Hosp 2026· OctRead

UGT1A1, ABCB1

Nanopore sequencing panel for saliva-based host pharmacogenomic screening in anti-tubercular therapy.

Drug-resistant tuberculosis

Adverse reactionPreemptive genotyping

medRxiv 2026· SepRead

The pharmacogGENEtics in Youth Depression (GENE-YD) study for personalizing antidepressant pharmacotherapy for young Western Australians - A feasibility study.

Major depressive disorder in young people aged 16 to 24

PsychiatryPreemptive genotyping

Transl Psychiatry 2026· AugRead

References and sources

DPYD — Severe fluoropyrimidine toxicity in solid tumors. Pharmgenomics Pers Med 2026. PMID 42921530. Score 6/10. https://pubmed.ncbi.nlm.nih.gov/42921530/
HLA-F, SLCO1B1, CYP3A4 — Trastuzumab deruxtecan-induced interstitial lung disease in advanced breast cancer. ESMO Open 2026. PMID 42901050. Score 6/10. https://pubmed.ncbi.nlm.nih.gov/42901050/
NUDT15, TPMT — Inflammatory bowel disease treated with azathioprine. Crohns Colitis 360 2026. PMID 42927292. Score 5/10. https://pubmed.ncbi.nlm.nih.gov/42927292/
Lipid-lowering cardiovascular prevention. medRxiv 2026. doi:10.64898/2026.10.18.26365857. Score 5/10. https://www.medrxiv.org/content/10.64898/2026.10.18.26365857v1
CYP2D6 — Systemic lupus erythematosus treated with hydroxychloroquine. Br J Clin Pharmacol 2026. PMID 42924549. Score 5/10. https://pubmed.ncbi.nlm.nih.gov/42924549/
NUDT15 — Pediatric-onset inflammatory bowel disease treated with thiopurines. Pediatr Neonatol 2026. PMID 42907239. Score 4/10. https://pubmed.ncbi.nlm.nih.gov/42907239/
TPMT, NUDT15, DPYD, UGT1A1 — Childhood cancers treated with antineoplastic agents. Farm Hosp 2026. PMID 42918680. Score 4/10. https://pubmed.ncbi.nlm.nih.gov/42918680/
UGT1A1, ABCB1 — Drug-resistant tuberculosis. medRxiv 2026. PMID 42922718. Score 4/10. https://pubmed.ncbi.nlm.nih.gov/42922718/
Major depressive disorder in young people aged 16 to 24. Transl Psychiatry 2026. PMID 42897167. Score 4/10. https://pubmed.ncbi.nlm.nih.gov/42897167/

20 October 2026