CYP2D6

Resolving CYP2D6 Structural Complexity with Long-Read Sequencing: Implications for Tamoxifen Precision Dosing in Thai Breast Cancer Patients.

CYP2D6 pharmacogenetics (tamoxifen)

Association between CYP2D6 and CYP2C19 genotypes and venlafaxine treatment failure: a retrospective study on two cohorts from Norway and the UK.

Major depression treated with venlafaxine

Tramadol Co-Administration with Oxycodone or Hydrocodone Increases Opioid Burden without Improving Postoperative Pain Control.

Postoperative pain - tramadol-opioid combination

Haplo2D6: a web-based tool for automated CYP2D6 haplotype and phenotype inference

CYP2D6 — Haplo2D6 web tool for automated metabolizer haplotype and phenotype inference from genotyping data

Effect of Individual and Combined Cytochrome P450 Activity Scores on Symptom Improvement and Side Effects in Youth Treated With Sertraline.

Pediatric mental health conditions treated with sertraline — side effects and symptom improvement by CYP450 genotype

Frequency of Key Pharmacogenes CYP2C9, CYP2C19, CYP2D6, and SLCO1B1 in the Yogyakarta Population: Implications for Precision Prescribing in Indonesia

PGx allele frequencies (CYP2C9, CYP2C19, CYP2D6, SLCO1B1) in the Yogyakarta population (Indonesia)

Economic effectiveness of pharmacogenomics-guided prescribing for psychiatric disorders: a systematic review and meta-analysis

Psychiatric disorders — economic efficiency of PGx genotyping

CYP2D6 Metabolizer Status and Mortality in Metoprolol Users

Cardiovascular disease — metoprolol therapy

Predicting Social Cognitive Outcomes in Adolescent-Onset Schizophrenia: A Hierarchical Analysis of Pharmacogenetic, Clinical, and Environmental Factors

Adolescent-onset schizophrenia — social cognition and CYP2D6 metabolism

Pharmacogenomics for stratified antidepressant treatment in major depressive disorder: evidence, limits and a roadmap for clinical use

Major depressive disorder — pharmacogenetics-guided antidepressant prescribing

Identification and drug metabolic activity evaluation of 12 CYP2D6 allelic variants newly detected in the Chinese population.

Pharmacogenetics — drug metabolism

A pilot study of pharmacogenomic testing as a tool to enhance depression care in Veterans

Depression in military veterans — implementation of multigene PGx genotyping

Analytical Validation of an Annotation Tool for WGS-Based Pharmacogenomics: Preparing for Clinical Implementation

Clinical implementation of WGS for pharmacogenetics — analytical validation

Pharmacogenetic Variability and Quality of Life in Adolescent Patients with Schizophrenia: The Impact of Metabolizer Status, Symptom Severity, and Adverse Reactions to Antipsychotic Treatment

CYP2D6 PGx variability and antipsychotic tolerability in adolescent schizophrenia patients

Association between CYP2D6 genotype and treatment effectiveness and safety in 99 hospitalized patients with major depressive disorder: a retrospective cohort study.

Major depressive disorder treated with antidepressants

CYP2D6 Metabolizer Phenotype Is Associated with Early Antidepressant Discontinuation in the UK Biobank

Early antidepressant discontinuation

Hydrocodone vs Oxycodone and Postoperative Pain and Opioid Use in Joint Arthroplasty.

Postoperative analgesia (joint arthroplasty)

Association of Atomoxetine Discontinuation Patterns with CYP2D6 Phenotype in Children and Adolescents with Attention Deficit Hyperactivity Disorder.

Attention-deficit/hyperactivity disorder (atomoxetine)

Does Next Generation Sequencing (NGS)-Based CYP2D6 Sequencing Improve Genotype-Phenotype Concordance in Tamoxifen-Treated Patients?

Breast cancer — tamoxifen and CYP2D6 phenotyping by NGS

Aripiprazole and CYP2D6: A retrospective cohort study evaluating the impact of phenotype on metabolic abnormalities.

Aripiprazole — metabolic abnormalities by CYP2D6 phenotype and phenoconversion

Amplicon-based long-read sequencing for accurate CYP2D6 gene deletion and duplication detection using CYP2D7 as a reference gene.

CYP2D6 pharmacogenetics

Current evidence supporting solanidine and its metabolites as biomarkers of CYP2D6 activity.

CYP2D6 functional phenotyping

Metoprolol Population Pharmacokinetics in Older Chinese Patients With CKM Syndrome: Joint Effects of rs1065852 and CKM2S2-BAG Score on Clearance.

Cardiovascular-kidney-metabolic syndrome in older adults — metoprolol exposure

Application of Physiologically Based Pharmacokinetic Modeling to Optimize Assessment of Age-Related Fluoxetine Accumulation in the Elderly.

Fluoxetine exposure in elderly patients

Pharmacogenomics in Dentistry: From CYP-Mediated Drug Response to Precision Prescribing in Oral Healthcare.

Drug prescribing in oral healthcare