Frequency of Key Pharmacogenes CYP2C9, CYP2C19, CYP2D6, and SLCO1B1 in the Yogyakarta Population: Implications for Precision Prescribing in Indonesia

Characterization of functional allele frequencies for CYP2C9/CYP2C19/CYP2D6/SLCO1B1 in an Indonesian population — implications for precision prescribing

Allele frequencies of CYP2C9, CYP2C19, CYP2D6, and SLCO1B1 are characterized in the Yogyakarta population, Indonesia. Pharmacogenomic allele frequency data are essential for implementing PGx guidelines in non-European populations. Indonesia, with 280 million inhabitants, is severely underrepresented in global PGx databases. These population-specific frequencies have direct implications for precision prescribing in this large yet underserved pharmacogenomic landscape. ⚠️ Summary written from title (RSS abstract unavailable — authors/PMID to verify via DOI).

Synthesis written by Geno'X. For the full original abstract, please refer to the source publication.

Southeast Asian populations remain among the most underrepresented in global PGx databases, despite having allele profiles sometimes markedly different from European or East Asian populations. Each population frequency study in these regions is a direct contribution to local pharmacogenomics implementation.

Clinical impact : 2/3 · Evidence strength : 2/3 · Novelty : 2/2 · Sample size : 1/1 · Journal quality : 1/1 → Total : 8/10