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Pharmacogenomics
Week of 13 May 2026
11 articles
Geno'X Veille — genox-veille.fr
Key takeaways this week
- ►100% of TCGA patients (n=10,302) carry at least one actionable germline pharmacogenetic variant — often more than somatic targets.
- ►CYP2C19 — metabolizer status predicts 5-year cardiovascular risk in men but not women after coronary stenting.
- ►DPYD/UGT1A1 — germline pharmacogenomics is more frequently actionable than somatic targets in precision oncology.
- ►HLA-B15:01* — AED pharmacogenomics in Asia: high allele frequencies justify systematic pre-treatment genotyping.
- ►CYP2D6 — combined CYP450 activity score predicts improvement and side effects on sertraline in youth aged 6–24.
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CYP2C19
PubMed★ Top pick
Sex Differences in Prognostic Implications of CYP2C19 Genotype After Drug-Eluting Stent Implantation.
Acute coronary syndrome on clopidogrel — CYP2C19 genotype prognostic effect differs by sex
9
/10
CardiologyRecurrent variantDose recommendation
J Am Heart Assoc 2026· MayRead
DPYD
PubMed★ Top pick
Integrating Somatic and Germline Pharmacogenomics for Therapeutic Decisions in Precision Oncology.
Pharmacogenomics in precision oncology — somatic + germline integration in 10,302 cancer patients (TCGA)
9
/10
OncologyPreemptive genotypingCPIC Level A
JCO Precis Oncol 2026· MayRead
FTO
PubMedFTO rs7195994 Is associated with TNF inhibitor response in lean rheumatoid arthritis patients: A BMI-stratified pharmacogenetic analysis.
Rheumatoid arthritis — TNF inhibitor non-response according to FTO genotype and BMI
8
/10
New interactionRecurrent variant
Pharmacogenomics J 2026· MayRead
CYP2D6
PubMedEffect of Individual and Combined Cytochrome P450 Activity Scores on Symptom Improvement and Side Effects in Youth Treated With Sertraline.
Pediatric mental health conditions treated with sertraline — side effects and symptom improvement by CYP450 genotype
8
/10
PhenoconversionDose recommendation
Clin Transl Sci 2026· MayRead
Statin-associated muscle symptoms (SAMS) — genetic determinants related to the coenzyme Q10 pathway
PubMedUncovering Coenzyme Q10-Related Genetic Determinants of Statin-Associated Muscle Symptoms: Evidence from the UK Biobank and the All of Us Research Program
Statin-associated muscle symptoms (SAMS) — genetic determinants related to the coenzyme Q10 pathway
8
/10
Adverse reactionNew interaction
Clin Pharmacol Ther 2026· MayRead
CYP2D6
PubMedFrequency of Key Pharmacogenes CYP2C9, CYP2C19, CYP2D6, and SLCO1B1 in the Yogyakarta Population: Implications for Precision Prescribing in Indonesia
PGx allele frequencies (CYP2C9, CYP2C19, CYP2D6, SLCO1B1) in the Yogyakarta population (Indonesia)
8
/10
DiabetesRecurrent variantPreemptive genotyping
Clin Pharmacol Ther 2026· AprRead
APOE
PubMedAPOE genotype and the effect of statins on lipid outcomes: A meta-analysis
Lipid response to statins by APOE genotype — meta-analysis
8
/10
Recurrent variantDose recommendation
Br J Clin Pharmacol 2026· FebRead
CYP2C19
PubMedLimited Visibility and Perception of the Clinical Relevance of Clopidogrel Pharmacogenetics in Cardiology Literature.
Under-implementation of clopidogrel pharmacogenetics in cardiology
7
/10
CardiologyNew recommendationRecurrent variant
Clin Transl Sci 2026· MayRead
CYP2C19
PubMedPharmacogenomic Profiling of Voriconazole Enables Predicting Its Toxicity in Pediatric Leukemia and Hematopoietic Stem Cell Transplant Recipients.
Voriconazole toxicity in pediatric leukemia and HSCT — prediction by CYP2C19 genotype
7
/10
Adverse reactionDose recommendation
J Clin Pharmacol 2026· MayRead
UGT1A1
PubMedConcentration dependency of an acyl glucuronide metabolite in eltrombopag-induced hepatotoxicity: Role of UGT1A1 genotype
Eltrombopag-induced hepatotoxicity (thrombopoietin receptor agonist) — role of UGT1A1 genotype
7
/10
Adverse reactionNew interaction
Br J Clin Pharmacol 2026· AprRead
HLA-B
PubMedPharmacogenomics in epilepsy care across Asia
Epilepsy in Asia — pharmacogenomics of antiepileptic drugs (HLA-B*15:01, HLA-A*31:01, SCN1A/CYP2C19)
7
/10
CPIC Level AAdverse reaction
Fam Cancer 2026· MayRead
References and sources
- FTO — Rheumatoid arthritis — TNF inhibitor non-response according to FTO genotype and BMI. Pharmacogenomics J 2026. PMID 42086550. Score 8/10. https://pubmed.ncbi.nlm.nih.gov/42086550/
- CYP2C19 — Acute coronary syndrome on clopidogrel — CYP2C19 genotype prognostic effect differs by sex. J Am Heart Assoc 2026. PMID 42047190. Score 9/10. https://pubmed.ncbi.nlm.nih.gov/42047190/
- CYP2C19 — Under-implementation of clopidogrel pharmacogenetics in cardiology. Clin Transl Sci 2026. PMID 42115787. Score 7/10. https://pubmed.ncbi.nlm.nih.gov/42115787/
- CYP2D6 — Pediatric mental health conditions treated with sertraline — side effects and symptom improvement by CYP450 genotype. Clin Transl Sci 2026. PMID 42115785. Score 8/10. https://pubmed.ncbi.nlm.nih.gov/42115785/
- CYP2C19 — Voriconazole toxicity in pediatric leukemia and HSCT — prediction by CYP2C19 genotype. J Clin Pharmacol 2026. PMID 42104599. Score 7/10. https://pubmed.ncbi.nlm.nih.gov/42104599/
- DPYD — Pharmacogenomics in precision oncology — somatic + germline integration in 10,302 cancer patients (TCGA). JCO Precis Oncol 2026. PMID 42090628. Score 9/10. https://pubmed.ncbi.nlm.nih.gov/42090628/
- Statin-associated muscle symptoms (SAMS) — genetic determinants related to the coenzyme Q10 pathway. Clin Pharmacol Ther 2026. PMID 42109163. Score 8/10. https://ascpt.onlinelibrary.wiley.com/doi/10.1002/cpt.70325?af=R
- CYP2D6 — PGx allele frequencies (CYP2C9, CYP2C19, CYP2D6, SLCO1B1) in the Yogyakarta population (Indonesia). Clin Pharmacol Ther 2026. PMID 42050991. Score 8/10. https://ascpt.onlinelibrary.wiley.com/doi/10.1002/cpt.70297?af=R
- UGT1A1 — Eltrombopag-induced hepatotoxicity (thrombopoietin receptor agonist) — role of UGT1A1 genotype. Br J Clin Pharmacol 2026. PMID 42050376. Score 7/10. https://bpspubs.onlinelibrary.wiley.com/doi/10.1002/bcp.70585?af=R
- APOE — Lipid response to statins by APOE genotype — meta-analysis. Br J Clin Pharmacol 2026. PMID 41702864. Score 8/10. https://bpspubs.onlinelibrary.wiley.com/doi/10.1002/bcp.70493?af=R
- HLA-B — Epilepsy in Asia — pharmacogenomics of antiepileptic drugs (HLA-B*15:01, HLA-A*31:01, SCN1A/CYP2C19). Fam Cancer 2026. PMID 42089916. Score 7/10. https://pubmed.ncbi.nlm.nih.gov/42104902/