Pharmacogenomics

Week of 15 September 2026

11 articles

Geno'X Veille — genox-veille.fr

Key takeaways this week

►DPYD — haplotype-based reading of the c.85, c.496 and c.2194 loci refines fluoropyrimidine toxicity prediction across 17,485 patients.
►CYP2D6 — poor metaboliser status doubles the risk of venlafaxine discontinuation, replicated in two independent European cohorts.
►CYP2C19 — a voriconazole initial dosing algorithm combines genotype and inflammation, but stays imprecise at both extremes.
►Pre-emptive genotyping — in Singapore, 18.4% of patients could have had their prescriptions modified by prior testing.
►CYP2C19 — a review recalls that genotype explains only 12% to 20% of the variability in clopidogrel response.

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DPYD c.85 T > C, DPYD c.496 A>G, and DPYD c.2194 G>A and severe toxicity to fluoropyrimidines in PREPARE and Alpe-DPD trials. An original study and meta-analysis.

Severe fluoropyrimidine-related toxicity

OncologyCPIC Level AAdverse reaction

Pharmacol Res 2026· SepRead

Association between CYP2D6 and CYP2C19 genotypes and venlafaxine treatment failure: a retrospective study on two cohorts from Norway and the UK.

Major depression treated with venlafaxine

PsychiatryPreemptive genotyping

Lancet Psychiatry 2026· SepRead

Development of a dosing algorithm integrating pharmacogenetic markers and inflammation for individualization of initial voriconazole maintenance doses.

Voriconazole antifungal therapy

Dose recommendationPhenoconversion

Antimicrob Agents Chemother 2026· SepRead

Prevalence of pharmacogenomically implicated prescriptions in multi-ethnic populations in Singapore.

Prescribing of pharmacogenomically implicated medicines

DiabetesPreemptive genotyping

Br J Clin Pharmacol 2026· SepRead

Barriers and facilitators to the implementation of pharmacogenomic testing for antidepressants use in primary care: a systematic review using the consolidated framework for implementation research.

Antidepressant prescribing in primary care

PsychiatryPreemptive genotyping

Pharmacogenomics J 2026· SepRead

Real-world pharmacogenomics-guided antihypertensive treatment response in clinical practice underrepresented population: implications for precision prescribing and medication safety.

Adult arterial hypertension

Recurrent variant

Eur J Clin Pharmacol 2026· SepRead

Recent research progress on the mechanisms of clopidogrel resistance.

Clopidogrel resistance

CardiologyCPIC Level A

Eur J Clin Pharmacol 2026· SepRead

Clobazam in pediatric drug-resistant epilepsy: from pharmacology to clinical practice.

Paediatric drug-resistant epilepsy

Dose recommendation

Eur J Clin Pharmacol 2026· SepRead

Comparative Safety and Efficacy of Dual Antiplatelet Therapy Regimens in Flow Diversion for Intracranial Aneurysms: a Systematic Review and Network Meta-Analysis.

Intracranial aneurysm treated with a flow diverter

Clin Neuroradiol 2026· SepRead

Clinical Outcomes of an ApoE Genotype-Guided Lipid-Lowering Strategy in Acute Coronary Syndrome Patients Undergoing Percutaneous Coronary Intervention.

Acute coronary syndrome after percutaneous coronary intervention

Dose recommendation

Pharmgenomics Pers Med 2026· SepRead

Association of germline ABCB1 and ERCC1 polymorphisms with CDK4/6 inhibitor-induced neutropenia in patients with breast cancer: a systematic review and meta-analysis.

CDK4/6 inhibitor-induced neutropenia in breast cancer

Adverse reaction

Front Pharmacol 2026· AugRead

References and sources

DPYD — Severe fluoropyrimidine-related toxicity. Pharmacol Res 2026. PMID 42727832. Score 8/10. https://pubmed.ncbi.nlm.nih.gov/42727832/
CYP2D6 — Major depression treated with venlafaxine. Lancet Psychiatry 2026. PMID 42716055. Score 8/10. https://pubmed.ncbi.nlm.nih.gov/42716055/
CYP3A5 — Adult arterial hypertension. Eur J Clin Pharmacol 2026. PMID 42722881. Score 5/10. https://pubmed.ncbi.nlm.nih.gov/42722881/
CYP2C19 — Voriconazole antifungal therapy. Antimicrob Agents Chemother 2026. PMID 42725959. Score 6/10. https://pubmed.ncbi.nlm.nih.gov/42725959/
Prescribing of pharmacogenomically implicated medicines. Br J Clin Pharmacol 2026. PMID 42740528. Score 6/10. https://pubmed.ncbi.nlm.nih.gov/42740528/
CYP2C19 — Clopidogrel resistance. Eur J Clin Pharmacol 2026. PMID 42706349. Score 5/10. https://pubmed.ncbi.nlm.nih.gov/42706349/
CYP2C19 — Paediatric drug-resistant epilepsy. Eur J Clin Pharmacol 2026. PMID 42717028. Score 5/10. https://pubmed.ncbi.nlm.nih.gov/42717028/
Antidepressant prescribing in primary care. Pharmacogenomics J 2026. PMID 42716951. Score 6/10. https://pubmed.ncbi.nlm.nih.gov/42716951/
Intracranial aneurysm treated with a flow diverter. Clin Neuroradiol 2026. PMID 42711420. Score 5/10. https://pubmed.ncbi.nlm.nih.gov/42711420/
APOE — Acute coronary syndrome after percutaneous coronary intervention. Pharmgenomics Pers Med 2026. PMID 42730005. Score 5/10. https://pubmed.ncbi.nlm.nih.gov/42730005/
ABCB1 — CDK4/6 inhibitor-induced neutropenia in breast cancer. Front Pharmacol 2026. PMID 42712445. Score 5/10. https://pubmed.ncbi.nlm.nih.gov/42712445/

8 September 2026