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Pharmacogenomics
Week of 22 September 2026
6 articles
Geno'X Veille — genox-veille.fr
Key takeaways this week
- ►CYP3A5 — genotype-guided dosing shortens time to tacrolimus steady state from 16 to 6 days in normal metabolisers, but underdoses poor metabolisers.
- ►DPYD — in 192 Mexican patients, actionable variants have a 0.26% allele frequency, ten-fold lower than in European cohorts.
- ►CYP2C19 — in a prediction model for clopidogrel platelet reactivity, genotype and proton pump inhibitor use weigh additively.
- ►ABCB1 — the rs2032582 non-GG plus rs1045642 non-CC combination predicts early neutropenia on gemcitabine plus nab-paclitaxel, and better survival.
- ►Adherence — only five of ten quantitative studies show an adherence gain after a pharmacogenetic result is returned.
6 articles of 6
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CYP3A5
PubMedDifferences in Early Tacrolimus Exposure in Kidney Transplant Recipients With and Without CYP3A5 Genotype-Guided Tacrolimus Dosing.
Kidney transplantation on tacrolimus
7
CPIC Level ADose recommendation
Clin Transl Sci 2026· SepRead
DPYD
PubMedCharacterization of DPYD pharmacogenetic variation in Mexican patients with gastrointestinal malignancies.
Fluoropyrimidine toxicity in gastrointestinal cancers
6
OncologyCPIC Level AAdverse reaction
Cancer Chemother Pharmacol 2026· SepRead
CYP2C19
PubMedDevelopment and validation of a clinical-pharmacogenomic prediction model for clopidogrel-related high on-treatment platelet reactivity in patients with coronary artery disease.
High on-treatment platelet reactivity on clopidogrel in coronary artery disease
6
CardiologyCPIC Level APhenoconversion
Front Cardiovasc Med 2026· SepRead
Pharmacogenomic variation in the Vietnamese population
PubMedVietnamese pharmacogenomic variation in global context: a systematic review and meta-analysis for clinical implementation.
Pharmacogenomic variation in the Vietnamese population
5
Preemptive genotypingRecurrent variant
Front Pharmacol 2026· SepRead
ABCB1
PubMedAssociation between ABCB1 genetic polymorphisms with treatment outcomes in patients with metastatic pancreatic cancer.
Early neutropenia on gemcitabine plus nab-paclitaxel
5
Adverse reactionRecurrent variant
Int J Clin Oncol 2026· SepRead
Medication adherence under pharmacogenetics-informed prescribing
PubMedThe impact of pharmacogenetic-informed care on medication adherence and psychological factors associated with adherence: A narrative review.
Medication adherence under pharmacogenetics-informed prescribing
5
Preemptive genotyping
Br J Clin Pharmacol 2026· SepRead
References and sources
- CYP3A5 — Kidney transplantation on tacrolimus. Clin Transl Sci 2026. PMID 42748365. Score 7/10. https://pubmed.ncbi.nlm.nih.gov/42748365/
- DPYD — Fluoropyrimidine toxicity in gastrointestinal cancers. Cancer Chemother Pharmacol 2026. PMID 42752660. Score 6/10. https://pubmed.ncbi.nlm.nih.gov/42752660/
- CYP2C19 — High on-treatment platelet reactivity on clopidogrel in coronary artery disease. Front Cardiovasc Med 2026. PMID 42757126. Score 6/10. https://pubmed.ncbi.nlm.nih.gov/42757126/
- Pharmacogenomic variation in the Vietnamese population. Front Pharmacol 2026. PMID 42756309. Score 5/10. https://pubmed.ncbi.nlm.nih.gov/42756309/
- ABCB1 — Early neutropenia on gemcitabine plus nab-paclitaxel. Int J Clin Oncol 2026. PMID 42762424. Score 5/10. https://pubmed.ncbi.nlm.nih.gov/42762424/
- Medication adherence under pharmacogenetics-informed prescribing. Br J Clin Pharmacol 2026. PMID 42749995. Score 5/10. https://pubmed.ncbi.nlm.nih.gov/42749995/