Pharmacogenomics

Week of 3 November 2026

7 articles

Geno'X Veille — genox-veille.fr

Key takeaways this week

►CYP2D6 — 17% of the 35,338 UK Biobank participants reporting a psychiatric disorder are estimated to be phenoconverted by their own prescription; a meta-analysis of 12 studies finds the same pooled prevalence.
►DPYD — in 687 phenotyped subjects, standardized markers detect only 12.77% of DPD deficiencies; adding rare variants and the rs1801160/rs2297595 co-occurrence raises sensitivity to 35.11%, with specificity falling to 91.74%.
►CYP2D6 — ADRED: in 659 patients aged 65 and over, intermediate and poor metabolizers exposed to anticholinergic drugs have a 3.32 chance of presenting with a fall, with no equivalent signal for CYP2C19.
►UGT1A1 / NR1I2 — in 221 people living with HIV in Thailand, combining the UGT1A1 poor metabolizer phenotype with the NR1I2 TT genotype reduces dolutegravir apparent clearance by 25.1%.
►Primary care — six core functions, from patient identification to modifying pharmacotherapy, are distinguished from local forms for rolling out pharmacogenomic testing.

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Drug-Induced CYP2D6 Phenoconversion Among Individuals with a Psychiatric Disorder: Prevalence and Association with Psychological Distress

CYP2D6 phenoconversion in individuals with a psychiatric disorder

PsychiatryPhenoconversionAdverse reaction

Pharmaceutics 2026· OctRead

UGT1A1, NR1I2

Impact of Body Weight and Combined UGT1A1 and NR1I2 Polymorphisms on Dolutegravir Pharmacokinetics Among Thai People Living with HIV: A Population Pharmacokinetic Analysis

HIV infection treated with dolutegravir

Dose recommendationAdverse reaction

Pharmaceutics 2026· OctRead

CYP2D6, CYP2C19

Fall-risk in genetic variable cytochrome P450 enzymes and exposure to anticholinergic drugs - a pilot-analysis from the ADRED-study

Falls on anticholinergic drugs in older adults

Adverse reactionRecurrent variant

Pharmacogenomics 2026· OctRead

Genotype-Phenotype Predictive Gap in Pre-Emptive Screening of DPD Deficiency: Improving Sensitivity

Dihydropyrimidine dehydrogenase deficiency and fluoropyrimidine toxicity

OncologyPreemptive genotypingAdverse reaction

Pharmaceuticals (Basel) 2026· SepRead

Blood pressure response to amlodipine in hypertension

Bayesian Additive Regression Trees modeling of pharmacogenomic and clinical data predicts amlodipine response in hypertension

Blood pressure response to amlodipine in hypertension

Recurrent variant

Pharmacogenet Genomics 2026· OctRead

Identification and in vitro functional assessment of 16 CYP2A6 variants detected in the Chinese Han population

Variability in CYP2A6 substrate metabolism in the Chinese Han population

Recurrent variant

Pharmacogenomics 2026· OctRead

Implementation of pharmacogenomic testing in primary care

Defining Core Functions and Forms for the Implementation of Pharmacogenomics Testing in Primary Care

Implementation of pharmacogenomic testing in primary care

Preemptive genotyping

Clin Transl Sci 2026· NovRead

References and sources

CYP2D6 — CYP2D6 phenoconversion in individuals with a psychiatric disorder. Pharmaceutics 2026. PMID 42942849. Score 8/10. https://pubmed.ncbi.nlm.nih.gov/42942849/
UGT1A1, NR1I2 — HIV infection treated with dolutegravir. Pharmaceutics 2026. PMID 42942777. Score 7/10. https://pubmed.ncbi.nlm.nih.gov/42942777/
CYP2D6, CYP2C19 — Falls on anticholinergic drugs in older adults. Pharmacogenomics 2026. PMID 42963339. Score 6/10. https://pubmed.ncbi.nlm.nih.gov/42963339/
DPYD — Dihydropyrimidine dehydrogenase deficiency and fluoropyrimidine toxicity. Pharmaceuticals (Basel) 2026. PMID 42943248. Score 6/10. https://pubmed.ncbi.nlm.nih.gov/42943248/
Blood pressure response to amlodipine in hypertension. Pharmacogenet Genomics 2026. PMID 42963859. Score 6/10. https://pubmed.ncbi.nlm.nih.gov/42963859/
CYP2A6 — Variability in CYP2A6 substrate metabolism in the Chinese Han population. Pharmacogenomics 2026. PMID 42944707. Score 5/10. https://pubmed.ncbi.nlm.nih.gov/42944707/
Implementation of pharmacogenomic testing in primary care. Clin Transl Sci 2026. PMID 42966874. Score 5/10. https://pubmed.ncbi.nlm.nih.gov/42966874/

27 October 2026