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Cancer genetics
Week of 23 June 2026
9 articles
Geno'X Veille — genox-veille.fr
Key takeaways this week
- ►RESET-C — a single neoadjuvant pembrolizumab cycle induces major response in dMMR colon cancer (Lynch syndrome).
- ►BRCA1/2 — occult lesions at prophylactic salpingo-oophorectomy: multicenter data on 291 carriers.
- ►Rucaparib — FDA-approved PARP inhibitor in germline BRCA prostate cancer, a new male paradigm.
9 articles of 9
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Lynch syndrome
PubMedNeoadjuvant Single-Cycle Pembrolizumab for Stage I-III MMR-Deficient Colon Cancer: The RESET-C Trial
MMR-deficient colorectal cancer — neoadjuvant immunotherapy
7
Lynch syndromeNew recommendation
J Clin Oncol 2026· JunRead
Breast cancer
Autosomal dominantPubMedGermline BRCA1 and BRCA2 mutations in specific different domains affect ovarian cancer prognosis: A multicenter retrospective study
Hereditary ovarian cancer — germline *BRCA1/2* variants by domain
7
Breast cancerPenetrance update
Chin Med J 2026· JunRead
Prophylactic surgery *BRCA1/2* — occult lesions at risk-reducing salpingo-oophorectomy
Autosomal dominantPubMedOccult invasive and preneoplastic lesions at risk-reducing salpingo-oophorectomy in BRCA1/2 carriers: A multicenter retrospective cohort study
Prophylactic surgery *BRCA1/2* — occult lesions at risk-reducing salpingo-oophorectomy
7
Prophylactic surgery
Gynecol Oncol 2026· JunRead
Lynch syndrome
Autosomal dominantPubMedLynch Syndrome and Ethnicity: Disparities in Prevalence, Affected Genes, Cancer Spectrum and Screening
Lynch syndrome — ethnic disparities
7
Lynch syndromeMainstreaming
Int J Cancer 2026· JunRead
Breast cancer
Autosomal dominantPubMedCharacterizing Breast Cancer Prevalence Among Female SDHx Pathogenic Variant Carriers in a Laboratory Research Registry
Breast cancer in *SDHx* pathogenic variant carriers
6
Breast cancerPenetrance update
Eur J Breast Health 2026· JulRead
Breast cancer
PubMedRucaparib — a PARP inhibitor for the treatment of BRCA-mutated metastatic castration-resistant prostate cancer
Metastatic castration-resistant prostate cancer — germline *BRCA* variants
6
Breast cancerPARP inhibitor
Future Oncol 2026· JunRead
Neurofibromatosis type 1 — malignant peripheral nerve sheath tumours (MPNST)
Autosomal dominantPubMedSurvival and prognosis of neurofibromatosis type 1-associated malignant peripheral nerve sheath tumours: a systematic review and meta-analysis
Neurofibromatosis type 1 — malignant peripheral nerve sheath tumours (MPNST)
6
Penetrance update
Orphanet J Rare Dis 2026· JunRead
BRCA1/2-associated hereditary pancreatic ductal adenocarcinoma
Autosomal dominantPubMedHistologic Spectrum of BRCA-Associated Pancreatic Ductal Adenocarcinoma: A Descriptive Morphologic Study
BRCA1/2-associated hereditary pancreatic ductal adenocarcinoma
6
Recurrent variant
Hum Pathol 2026· JunRead
Prophylactic surgery *BRCA1/2* — concurrent hysterectomy
Autosomal dominantPubMedInternational Trends in Concurrent Hysterectomy at Risk-Reducing Surgery in BRCA1/2 pathogenic variant carriers: A mixed-methods study
Prophylactic surgery *BRCA1/2* — concurrent hysterectomy
6
Prophylactic surgery
Am J Obstet Gynecol 2026· JunRead
References and sources
- MMR-deficient colorectal cancer — neoadjuvant immunotherapy. J Clin Oncol 2026. PMID 42085635. Score 7/10. https://pubmed.ncbi.nlm.nih.gov/42085635/
- Hereditary ovarian cancer — germline *BRCA1/2* variants by domain. Chin Med J 2026. PMID 40709810. Score 7/10. https://pubmed.ncbi.nlm.nih.gov/40709810/
- Prophylactic surgery *BRCA1/2* — occult lesions at risk-reducing salpingo-oophorectomy. Gynecol Oncol 2026. PMID 42320275. Score 7/10. https://pubmed.ncbi.nlm.nih.gov/42320275/
- Lynch syndrome — ethnic disparities. Int J Cancer 2026. PMID 42318823. Score 7/10. https://pubmed.ncbi.nlm.nih.gov/42318823/
- Breast cancer in *SDHx* pathogenic variant carriers. Eur J Breast Health 2026. PMID 42317087. Score 6/10. https://pubmed.ncbi.nlm.nih.gov/42317087/
- Metastatic castration-resistant prostate cancer — germline *BRCA* variants. Future Oncol 2026. PMID 42312474. Score 6/10. https://pubmed.ncbi.nlm.nih.gov/42312474/
- Neurofibromatosis type 1 — malignant peripheral nerve sheath tumours (MPNST). Orphanet J Rare Dis 2026. PMID 42310813. Score 6/10. https://pubmed.ncbi.nlm.nih.gov/42310813/
- BRCA1/2-associated hereditary pancreatic ductal adenocarcinoma. Hum Pathol 2026. PMID 42309195. Score 6/10. https://pubmed.ncbi.nlm.nih.gov/42309195/
- Prophylactic surgery *BRCA1/2* — concurrent hysterectomy. Am J Obstet Gynecol 2026. PMID 42323120. Score 6/10. https://pubmed.ncbi.nlm.nih.gov/42323120/
